An 8-Year Clinical Outcome of Posterior Inlay Retained Resin Bonded Fixed Dental Prosthesis Utilizing High Performance Polymer Materials: A Clinical Report.
- 作者列表："Tasopoulos T","Pachiou A","Kouveliotis G","Karaiskou G","Ottenga M","Zoidis P
:This clinical report presents the use of a modified polyetheretherketone (PEEK) Inlay Retained Resin Bonded Fixed Dental Prosthesis (IRRBFDP) framework, veneered with indirect high impact composite for the bilateral restoration of mandibular first molar teeth, as the most conservative treatment option for a medically compromised patient. When used as a framework, PEEK's elastic modulus (approximately 4 GPa), could result in the reduction of stresses transferred to the abutment teeth and the cementation interface accordingly, therefore it could result in lower de-bonding rates and higher success rates. Furthermore, the high bond strength with the veneering composite material and the luting cements permit its use for resin-bonded restorations. Preparation guidelines, indications and advantages for the fabrication of IRRBFDPs are described in this clinical report. No technical complications such as de-bonding of the framework, connector or retainer fracture of the adhesive frameworks or loss of retention were observed during the course of 8 years. Prosthetic replacement of single missing posterior mandibular teeth utilizing IRRBFDPs with high performance polymer materials could potentially offer long-term high survival rate outcomes. Further clinical evidence is required in order to justify the above statement.
: 本临床报告介绍了使用改良的聚醚醚酮 (PEEK) 嵌体保留的树脂粘合固定牙科修复体 (IRRBFDP) 框架，与间接高冲击复合材料一起用于下颌第一磨牙的双侧修复，作为医学上受损患者的最保守的治疗选择。当用作框架时，PEEK的弹性模量 (大约4 gpa) 可以相应地导致传递到基牙和胶结界面的应力的减少，因此它可以导致较低的脱粘率和较高的成功率。此外，与贴面复合材料和粘固剂的高粘结强度允许其用于树脂粘结的修复体。本临床报告中描述了制备IRRBFDPs的制备指南、适应症和优点。在8年的过程中没有观察到技术上的并发症，例如框架的脱粘、连接器或粘合剂框架的保持器断裂或保留损失。使用高性能聚合物材料使用IRRBFDPs修复单个缺失的下颌后牙可能提供长期高存活率的结果。为了证明上述陈述的合理性，需要进一步的临床证据。
METHODS::The ATP binding-cassette superfamily corresponds the mostly transmembrane transporters family found in humans. These proteins actively transport endogenous and exogenous substrates through biological membranes in body tissues, so they have an important role in the regulation of many physiological functions necessary for human homeostasis, as well as in response regulation to several pharmacological substrates. The development of multidrug resistance has become one of the main troubles in conventional chemotherapy in different illnesses including cancer, being the increased efflux of antineoplastic drugs the main reason for this multidrug resistance, with a key role of the ABC superfamily. Likely, the interindividual variability in the pharmacological response among patients is well known, and may be due to intrinsically factors of the disease, genetic and environmental ones. Thus, the understanding of this variability, especially the genetic variability associated with the efficacy and toxicity of drugs, can provide a safer and more effective pharmacological treatment, so ABC genes are considered as important regulators due to their relationship with the reduction in pharmacological response. In this review, updated information about transporters belonging to this superfamily was collected, the possible role of these transporters in cancer, the role of genetic variability in their genes, as well as some therapeutic tools that have been tried to raise against main transporters associated with chemoresistance in cancer.
METHODS:BACKGROUND:Cholinergic neurotransmission regulates neuroinflammation in Parkinson disease (PD). RESEARCH DESIGN AND METHODS:The authors conducted a delayed-start study of donepezil for cognitive decline in non-demented PD patients. The study consisted of a 96-week randomized placebo-controlled double-blind phase 1, followed by a 24-week donepezil extension phase 2. The primary outcome measure was a change in the Mini-Mental State Examination (MMSE) at week 120. RESULTS:A total of 98 patients were randomly allocated to the early-start (donepezil-to-donepezil) and delayed-start (placebo-to-donepezil) groups. Mean (SD) of the baseline MMSE was 27.6 (2.0) and 28.0 (2.1), respectively. MMSE change at week 120 was better in the early-start group than in the delayed-start group, but the difference was not significant. The MMSE declined in apolipoprotein ε4 carriers, but not in non-carriers, and the factor interaction (intervention × ε4 genotype) was highly significant (P < 0.001). Analyzed with the interaction, the difference was significant (group difference 1.95 [0.33 to 3.57], P = 0.018). The MMSE decline slope in phase 1 was significantly better in the early-start group than in the delayed-start group (P = 0.048). CONCLUSIONS:Cognitive function deteriorated in ε4 carriers, but not in non-carriers, and early-start donepezil may postpone cognitive decline in the former.
METHODS::Since the discovery of dental pulp stem cells, a lot of teams have expressed an interest in dental pulp regeneration. Many approaches, experimental models and biological explorations have been developed, each including the use of stem cells and scaffolds with the final goal being clinical application in humans. In this review, the authors' objective was to compare the experimental models and strategies used for the development of biomaterials for tissue engineering of dental pulp with stem cells. Electronic queries were conducted on PubMed using the following terms: pulp regeneration, scaffold, stem cells, tissue engineering and biomaterial. The extracted data included the following information: the strategy envisaged, the type of stem cells, the experimental models, the exploration or analysis methods, the cytotoxicity or viability or proliferation cellular tests, the tests of scaffold antibacterial properties and take into account the vascularization of the regenerated dental pulp. From the 71 selected articles, 59% focused on the "cell-transplantation" strategy, 82% used in vitro experimentation, 58% in vivo animal models and only one described an in vivo in situ human clinical study. 87% used dental pulp stem cells. A majority of the studies reported histology (75%) and immunohistochemistry explorations (66%). 73% mentioned the use of cytotoxicity, proliferation or viability tests. 48% took vascularization into account but only 6% studied the antibacterial properties of the scaffolds. This article gives an overview of the methods used to regenerate dental pulp from stem cells and should help researchers create the best development strategies for research in this field.