Automatic Digital Design of the Occlusal Anatomy of Monolithic Zirconia Crowns Compared to Dental Technicians' Digital Waxing: A Controlled Clinical Trial.
- 作者列表："Fiore AD","Monaco C","Brunello G","Granata S","Stellini E","Yilmaz B
PURPOSE:Reconstructing the occlusal morphology of posterior teeth in definitive dental prosthesis can be challenging. The use of the correlation technique enables replication of the information and occlusal anatomy of interim dental prostheses to the definitive ones. The purpose of this controlled clinical trial was to compare the static and dynamic contacts (SDC) of monolithic zirconia crowns designed with correlation and library techniques. MATERIAL AND METHODS:Twenty-four patients were included in the study for a total of 28 molars. For each abutment tooth, an interim crown was fabricated and two digital scans, with and without the interim crown in place were made. Two single crowns were designed using correlation and library techniques. Fifty-six monolithic zirconia crowns were milled. The interim and definitive crowns were evaluated intraorally for SDC by using a 24-μm-thick blue articulating foil. After removing the interim and definite crowns, extraoral photographs were taken to calculate the SDC area using software (ImageJ) and analyzed by the Kruskal-Wallis test. RESULTS:The average and ± standard deviation (SD) of area of the occlusal marks on interim crowns was 32.27 ± 3.45 mm2 . Definitive crowns designed by using the correlation technique had an area of 31.01 ± 3.73 mm2 ; the area in the library technique was 36.85 ± 5.78 mm2 . No statistically significant difference was found (p = 0.091) between the occlusal mark areas of the interim and definitive crowns designed by using the correlation technique. Whereas, there were significant differences between the areas of occlusal marks of the interim and definitive crowns designed by using the library technique, and between the areas of occlusal marks of definitive crowns designed by using the correlation and library techniques (p < 0.001). CONCLUSION:The average area of the SDC of monolithic zirconia crowns designed by using the correlation technique was similar to that of interim crowns. The library technique was less effective when replicating the SDC compared to the correlation technique.
目的: 在定形牙修复中重建后牙的咬合形态具有挑战性。相关技术的使用使得能够将临时假牙的信息和咬合解剖结构复制为明确的假牙。本对照临床试验的目的是比较用相关性和库技术设计的整体氧化锆冠的静态和动态接触 (SDC)。 材料和方法: 24名患者被纳入研究，共28颗磨牙。对于每颗基牙，制作一个临时牙冠，并在临时牙冠就位和不就位的情况下进行两次数字扫描。使用相关和图书馆技术设计了两个单冠。研磨了56个整块氧化锆冠。通过使用24μm m厚的蓝色关节箔，对中期和确定性牙冠进行了SDC的口内评估。在移除临时和明确的牙冠后，使用软件 (ImageJ) 拍摄口外照片以计算SDC面积，并通过Kruskal-Wallis测试进行分析。 结果: 中间牙冠咬合痕面积的平均值和 ± 标准差 (SD) 为32.27 ± 3.45平方毫米。使用相关技术设计的最终冠的面积为31.01 ± 3.73平方毫米; 库技术中的面积为36.85 ± 5.78平方毫米。使用相关技术设计的中期牙冠和最终牙冠的咬合标记区域之间没有发现统计学显著差异 (p = 0.091)。然而，使用库技术设计的中期牙冠和确定性牙冠的咬合标记面积之间以及使用相关性和库技术设计的确定性牙冠的咬合标记面积之间存在显著差异 (p <0.001)。 结论: 采用相关技术设计的整块氧化锆全冠SDC平均面积与中期全冠相似。与相关技术相比，文库技术在复制SDC时效果较差。
METHODS::The ATP binding-cassette superfamily corresponds the mostly transmembrane transporters family found in humans. These proteins actively transport endogenous and exogenous substrates through biological membranes in body tissues, so they have an important role in the regulation of many physiological functions necessary for human homeostasis, as well as in response regulation to several pharmacological substrates. The development of multidrug resistance has become one of the main troubles in conventional chemotherapy in different illnesses including cancer, being the increased efflux of antineoplastic drugs the main reason for this multidrug resistance, with a key role of the ABC superfamily. Likely, the interindividual variability in the pharmacological response among patients is well known, and may be due to intrinsically factors of the disease, genetic and environmental ones. Thus, the understanding of this variability, especially the genetic variability associated with the efficacy and toxicity of drugs, can provide a safer and more effective pharmacological treatment, so ABC genes are considered as important regulators due to their relationship with the reduction in pharmacological response. In this review, updated information about transporters belonging to this superfamily was collected, the possible role of these transporters in cancer, the role of genetic variability in their genes, as well as some therapeutic tools that have been tried to raise against main transporters associated with chemoresistance in cancer.
METHODS:BACKGROUND:Cholinergic neurotransmission regulates neuroinflammation in Parkinson disease (PD). RESEARCH DESIGN AND METHODS:The authors conducted a delayed-start study of donepezil for cognitive decline in non-demented PD patients. The study consisted of a 96-week randomized placebo-controlled double-blind phase 1, followed by a 24-week donepezil extension phase 2. The primary outcome measure was a change in the Mini-Mental State Examination (MMSE) at week 120. RESULTS:A total of 98 patients were randomly allocated to the early-start (donepezil-to-donepezil) and delayed-start (placebo-to-donepezil) groups. Mean (SD) of the baseline MMSE was 27.6 (2.0) and 28.0 (2.1), respectively. MMSE change at week 120 was better in the early-start group than in the delayed-start group, but the difference was not significant. The MMSE declined in apolipoprotein ε4 carriers, but not in non-carriers, and the factor interaction (intervention × ε4 genotype) was highly significant (P < 0.001). Analyzed with the interaction, the difference was significant (group difference 1.95 [0.33 to 3.57], P = 0.018). The MMSE decline slope in phase 1 was significantly better in the early-start group than in the delayed-start group (P = 0.048). CONCLUSIONS:Cognitive function deteriorated in ε4 carriers, but not in non-carriers, and early-start donepezil may postpone cognitive decline in the former.
METHODS::Since the discovery of dental pulp stem cells, a lot of teams have expressed an interest in dental pulp regeneration. Many approaches, experimental models and biological explorations have been developed, each including the use of stem cells and scaffolds with the final goal being clinical application in humans. In this review, the authors' objective was to compare the experimental models and strategies used for the development of biomaterials for tissue engineering of dental pulp with stem cells. Electronic queries were conducted on PubMed using the following terms: pulp regeneration, scaffold, stem cells, tissue engineering and biomaterial. The extracted data included the following information: the strategy envisaged, the type of stem cells, the experimental models, the exploration or analysis methods, the cytotoxicity or viability or proliferation cellular tests, the tests of scaffold antibacterial properties and take into account the vascularization of the regenerated dental pulp. From the 71 selected articles, 59% focused on the "cell-transplantation" strategy, 82% used in vitro experimentation, 58% in vivo animal models and only one described an in vivo in situ human clinical study. 87% used dental pulp stem cells. A majority of the studies reported histology (75%) and immunohistochemistry explorations (66%). 73% mentioned the use of cytotoxicity, proliferation or viability tests. 48% took vascularization into account but only 6% studied the antibacterial properties of the scaffolds. This article gives an overview of the methods used to regenerate dental pulp from stem cells and should help researchers create the best development strategies for research in this field.