- 作者列表："Yarborough AB","Clark WA","Givan DA","De Kok IJ
PURPOSE: The purpose of this survey was to assess dental laboratory technicians' perceptions of the quality of communication and techniques used when receiving removable prosthodontic cases. Additionally, responses were compared to a 2009 survey and changes in trends were evaluated. MATERIALS AND METHODS: An eleven-question anonymous response survey was developed based on a 2009 survey that assessed dental laboratory technicians' perceptions. The survey was distributed via Qualtrics to members of the National Association of Dental Laboratories (NADL) The survey included questions related to detail of instruction, quality of work received, design of the prosthesis, and type of articulator used. Responses were compared to those received in 2009. RESULTS: Fifty-two survey responses were received from dental laboratory technicians. Of these, 12 did not provide removable prosthodontics services and were excluded. The remaining 40 responses were analyzed. Of these, only 3.7% of the responding laboratory technicians reported receiving work authorizations from dentists that were complete enough to do their best work. While roughly half of the respondents (48.49%) expected a dentist to send a design for a cast partial denture framework, most respondents (72.5%) answered that they designed the majority of the partial denture frameworks they fabricated. The majority of respondents reported that complete denture impressions were not border molded in custom trays, and that most dentists did not rearrange or modify a wax setup for complete or partial dentures. These findings were consistent with the trends reported in the 2009 survey. CONCLUSIONS: Most dental laboratory technicians answered that based on their selected techniques, dentists tend to complete clinical procedures that minimize patient chair time. While the surveyed technicians appeared satisfied with the quality of work they received, there was a consistent message that communication was frequently inadequate, limiting the technicians ability to fabricate their best work.
目的: 本调查的目的是评估牙科实验室技术人员对接受可移动修复病例时使用的通信和技术质量的看法。此外，将回复与2009调查进行了比较，并评估了趋势的变化。 材料和方法: 一项11个问题的匿名回答调查是基于一项评估牙科实验室技术人员感知的2009调查而开发的。该调查通过Qualtrics分发给全国牙科实验室协会 (NADL) 的成员。该调查包括与教学细节、接受的工作质量、假体设计和使用的咬合器类型相关的问题。将答复与2009年收到的答复进行了比较。 结果: 从牙科实验室技术人员收到52份调查回复。其中12例未提供可摘式口腔修复服务，被排除。分析其余40个反应。其中，只有3.7% 的回应实验室技术人员报告收到牙医的工作授权，这些授权足够完成他们的最佳工作。虽然大约一半的受访者 (48.49%) 期望牙医发送铸造局部义齿框架的设计，但大多数受访者 (72.5%) 回答说他们设计了他们制造的大部分局部义齿框架。大多数受访者报告说，全口义齿印模不是在定制托盘中成型的边界，大多数牙医没有重新安排或修改全口或局部义齿的蜡设置。这些发现与2009调查中报告的趋势一致。 结论: 大多数牙科实验室技术人员回答说，根据他们选择的技术，牙医倾向于完成临床程序，尽量减少患者的椅子时间。□ 虽然接受调查的技术人员似乎对他们收到的工作质量感到满意，但有一个一致的信息，即沟通经常不足，限制了技术人员制作他们最好的工作的能力。
METHODS::The ATP binding-cassette superfamily corresponds the mostly transmembrane transporters family found in humans. These proteins actively transport endogenous and exogenous substrates through biological membranes in body tissues, so they have an important role in the regulation of many physiological functions necessary for human homeostasis, as well as in response regulation to several pharmacological substrates. The development of multidrug resistance has become one of the main troubles in conventional chemotherapy in different illnesses including cancer, being the increased efflux of antineoplastic drugs the main reason for this multidrug resistance, with a key role of the ABC superfamily. Likely, the interindividual variability in the pharmacological response among patients is well known, and may be due to intrinsically factors of the disease, genetic and environmental ones. Thus, the understanding of this variability, especially the genetic variability associated with the efficacy and toxicity of drugs, can provide a safer and more effective pharmacological treatment, so ABC genes are considered as important regulators due to their relationship with the reduction in pharmacological response. In this review, updated information about transporters belonging to this superfamily was collected, the possible role of these transporters in cancer, the role of genetic variability in their genes, as well as some therapeutic tools that have been tried to raise against main transporters associated with chemoresistance in cancer.
METHODS:BACKGROUND:Cholinergic neurotransmission regulates neuroinflammation in Parkinson disease (PD). RESEARCH DESIGN AND METHODS:The authors conducted a delayed-start study of donepezil for cognitive decline in non-demented PD patients. The study consisted of a 96-week randomized placebo-controlled double-blind phase 1, followed by a 24-week donepezil extension phase 2. The primary outcome measure was a change in the Mini-Mental State Examination (MMSE) at week 120. RESULTS:A total of 98 patients were randomly allocated to the early-start (donepezil-to-donepezil) and delayed-start (placebo-to-donepezil) groups. Mean (SD) of the baseline MMSE was 27.6 (2.0) and 28.0 (2.1), respectively. MMSE change at week 120 was better in the early-start group than in the delayed-start group, but the difference was not significant. The MMSE declined in apolipoprotein ε4 carriers, but not in non-carriers, and the factor interaction (intervention × ε4 genotype) was highly significant (P < 0.001). Analyzed with the interaction, the difference was significant (group difference 1.95 [0.33 to 3.57], P = 0.018). The MMSE decline slope in phase 1 was significantly better in the early-start group than in the delayed-start group (P = 0.048). CONCLUSIONS:Cognitive function deteriorated in ε4 carriers, but not in non-carriers, and early-start donepezil may postpone cognitive decline in the former.
METHODS::Since the discovery of dental pulp stem cells, a lot of teams have expressed an interest in dental pulp regeneration. Many approaches, experimental models and biological explorations have been developed, each including the use of stem cells and scaffolds with the final goal being clinical application in humans. In this review, the authors' objective was to compare the experimental models and strategies used for the development of biomaterials for tissue engineering of dental pulp with stem cells. Electronic queries were conducted on PubMed using the following terms: pulp regeneration, scaffold, stem cells, tissue engineering and biomaterial. The extracted data included the following information: the strategy envisaged, the type of stem cells, the experimental models, the exploration or analysis methods, the cytotoxicity or viability or proliferation cellular tests, the tests of scaffold antibacterial properties and take into account the vascularization of the regenerated dental pulp. From the 71 selected articles, 59% focused on the "cell-transplantation" strategy, 82% used in vitro experimentation, 58% in vivo animal models and only one described an in vivo in situ human clinical study. 87% used dental pulp stem cells. A majority of the studies reported histology (75%) and immunohistochemistry explorations (66%). 73% mentioned the use of cytotoxicity, proliferation or viability tests. 48% took vascularization into account but only 6% studied the antibacterial properties of the scaffolds. This article gives an overview of the methods used to regenerate dental pulp from stem cells and should help researchers create the best development strategies for research in this field.