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Borderline ovarian tumors in Denmark 1997-2018: Time trends in incidence by histology, age and educational level.

丹麦交界性卵巢肿瘤1997-2018: 组织学、年龄和教育水平发病率的时间趋势。

  • 影响因子:2.21
  • DOI:10.1111/aogs.14013
  • 作者列表:"Baandrup L","Faber MT","Aalborg GL","Kjaer SK
  • 发表时间:2021-03-01
Abstract

INTRODUCTION:After some decades with an increasing incidence of borderline ovarian tumors, more recent studies have observed that the incidence rate seems to be leveling off or declining. In this study, we describe the incidence of borderline ovarian tumors in Denmark 1997-2018 by histology, age at diagnosis and educational level. MATERIAL AND METHODS:All borderline ovarian tumors registered in the Danish Pathology Registry during 1997-2018 were identified and individual-level educational information was retrieved from nationwide registers. Age-standardized incidence rates were estimated according to histology, age at diagnosis and educational level. To investigate incidence trends over time, the average annual percentage change and corresponding 95% confidence intervals (CIs) were estimated using Poisson regression. RESULTS:We identified 3927 women with borderline ovarian tumors during the study period, of which 1997 (50.9%) were serous and 1743 (44.4%) were mucinous. The age-standardized incidence rate of serous borderline ovarian tumors did not change significantly over calendar time (average annual percentage change = -0.13, 95% confidence interval [CI] -1.13 to 0.88). For mucinous tumors, the age-standardized incidence rate was also relatively stable during the first half of the study period, followed by a decrease from 2.56 to 1.25 per 100 000 person-years between 2007-2011 and 2017-2018. Over the entire study period, the incidence rate of mucinous borderline tumors declined on average by 2.91% (95% CI -4.24 to -1.51) per year. The incidence of both types of borderline ovarian tumors seemed to be highest among women with a low educational level. Over calendar time, the incidence of mucinous tumors decreased in all educational groups, whereas the incidence of serous tumors decreased exclusively in women with a high educational level. Time trends did not differ markedly by age at diagnosis. CONCLUSIONS:In Denmark, the incidence of serous borderline ovarian tumors was stable during 1997-2018, whereas the incidence of mucinous borderline ovarian tumors decreased. The incidence rates of both types of borderline ovarian tumors tended to be highest among women with a low educational level throughout the study period.

摘要

引言: 随着交界性卵巢肿瘤发病率的增加,几十年后,最近的研究发现发病率似乎正在趋于平稳或下降。在这项研究中,我们通过组织学、诊断年龄和教育水平描述了丹麦1997-2018交界性卵巢肿瘤的发病率。 材料和方法: 确定1997-2018期间在丹麦病理学登记处登记的所有交界性卵巢肿瘤,并从全国范围内的登记处检索个体水平的教育信息。根据组织学、诊断年龄和教育水平估计年龄标准化发病率。为了研究发病率随时间的变化趋势,使用泊松回归估计平均年百分比变化和相应的95% 置信区间 (ci)。 结果: 我们在研究期间确定了3927例卵巢交界性肿瘤患者,其中1997例 (50.9%) 为浆液性,1743例 (44.4%) 为黏液性。浆液性交界性卵巢肿瘤的年龄标准化发病率随日历时间没有显著变化 (平均年百分比变化 = -0.13,95% 置信区间 [CI] -1.13至0.88)。对于粘液性肿瘤,年龄标准化的发病率在研究的前半段期间也相对稳定,随后在2.56-1.25和100-2007之间每2011 000人年从2017下降到2018。在整个研究期间,黏液性交界性肿瘤的发病率平均每年下降2.91% (95% CI -4.24至-1.51)。两种类型的交界性卵巢肿瘤的发病率似乎在低教育水平的女性中最高。随着日历时间的推移,粘液性肿瘤的发病率在所有教育群体中降低,而浆液性肿瘤的发病率仅在具有高教育水平的女性中降低。时间趋势在诊断时的年龄没有显著差异。 结论: 在丹麦,浆液性交界性卵巢肿瘤的发病率在1997-2018期间是稳定的,而黏液性交界性卵巢肿瘤的发病率下降。在整个研究期间,两种类型的交界性卵巢肿瘤的发病率在教育水平低的女性中往往最高。

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