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Impact of postoperative infectious complications on adjuvant chemotherapy administration after gastrectomy for advanced gastric cancer.

进展期胃癌术后感染并发症对术后辅助化疗的影响 [j].

  • 影响因子:2.04
  • DOI:10.1093/jjco/hyaa223
  • 作者列表:"Tsujimoto H","Kouzu K","Sugasawa H","Nomura S","Ito N","Harada M","Sugihara T","Ishibashi Y","Kishi Y","Ueno H
  • 发表时间:2021-03-03
Abstract

BACKGROUND:The aim of this study was to investigate the impact of postoperative infectious complications on adjuvant chemotherapy administration in patients with gastric cancer. METHODS:A retrospective review of 308 patients who underwent curative resection for gastric cancer was performed. Patients were divided into two groups based on the presence (90 patients, 29.2%) or absence (218 patients, 70.8%) of postoperative infectious complications to analyze clinicopathological characteristics, treatment factors and survival. RESULTS:Fewer patients with postoperative infectious complication received adjuvant chemotherapy compared to those without postoperative infectious complication. The proportion of patients who started treatment within 6 weeks after surgery was significantly lower in patients with postoperative infectious complication. The treatment completion rate was significantly lower in patients with postoperative infectious complication. The number of treatment cycles and relative dose intensity was significantly lower in patients with postoperative infectious complication. In univariate analysis, only postoperative infectious complication was significantly associated with continuation of adjuvant chemotherapy. Multivariate analysis demonstrated tumor depth, nodal involvement, postoperative infectious complication and adjuvant chemotherapy were significantly associated with overall survival. CONCLUSION:Postoperative infectious complications are significantly associated with the delay of adjuvant chemotherapy and predict adverse clinical outcome in patients with gastric cancer.

摘要

背景: 本研究旨在探讨胃癌患者术后感染并发症对辅助化疗的影响。 方法: 回顾性分析308例胃癌根治术患者的临床资料。根据有无术后感染并发症 (90例,29.2%) 或有无术后感染并发症 (218例,70.8%) 将患者分为两组,分析临床病理特征、治疗因素及生存情况。 结果: 与无术后感染并发症的患者相比,术后感染并发症的患者接受辅助化疗的患者较少。在术后感染并发症患者中,术后6周内开始治疗的患者比例明显较低。术后感染并发症患者的治疗完成率明显较低。术后感染并发症患者的治疗周期数和相对剂量强度显著降低。在单因素分析中,只有术后感染性并发症与继续辅助化疗显著相关。多因素分析显示肿瘤深度、淋巴结转移、术后感染并发症和辅助化疗与总生存期显著相关。 结论: 胃癌术后感染性并发症与辅助化疗的延迟和不良临床预后显著相关。

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