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A novel two-component, expandable bioadhesive for exposed defect coverage: Applicability to prenatal procedures.

一种用于暴露缺陷覆盖的新型双组分可膨胀生物粘合剂: 对产前手术的适用性。

  • 影响因子:2.14
  • DOI:10.1016/j.jpedsurg.2020.09.030
  • 作者列表:"Lazow SP","Labuz DF","Freedman BR","Rock A","Zurakowski D","Mooney DJ","Fauza DO
  • 发表时间:2021-01-01
Abstract

BACKGROUND/PURPOSE:We sought to test select properties of a novel, expandable bioadhesive composite that allows for enhanced adhesion control in liquid environments. METHODS:Rabbit fetuses (n = 23) underwent surgical creation of spina bifida on gestational day 22-25 (term 32-33 days). Defects were immediately covered with a two-component tough adhesive consisting of a hydrogel made of a double network of ionically crosslinked alginate and covalently crosslinked polyacrylamide linked to a bridging chitosan polymer adhesive. Animals were euthanized prior to term for different analyses, including hydraulic pressure testing. RESULTS:Hydrogels remained adherent in 70% (16/23) of the recovered fetuses and in all of the last 14 fetuses as the procedure was optimized. Adherent hydrogels showed a median two-fold (IQR: 1.7-2.4) increase in area at euthanasia, with defect coverage confirmed by ultrasound and histology. The median maximum pressure to repair failure was 15 mmHg (IQR: 7.8-55.3), exceeding reported neonatal cerebrospinal fluid pressures. CONCLUSIONS:This novel bioadhesive composite allows for selective, stable attachment of an alginate-polyacrylamide hydrogel to specific areas of the spina bifida defect in a fetal rabbit model, while the hydrogel expands with the defect over time. It could become a valuable alternative for the prenatal repair of spina bifida and possibly other congenital anomalies. TYPE OF STUDY:N/A (animal and laboratory study). LEVEL OF EVIDENCE:N/A (animal and laboratory study).

摘要

背景/目的: 我们试图测试一种新型可膨胀生物粘附复合材料的选择性能,该复合材料允许在液体环境中增强粘附控制。 方法: 兔胎儿 (n = 23) 在妊娠第22-25天 (孕32-33天) 进行脊柱裂手术。缺陷立即用双组分坚韧粘合剂覆盖,该粘合剂由由离子交联的藻酸盐和共价交联的聚丙烯酰胺的双网络制成的水凝胶与桥接壳聚糖聚合物粘合剂连接。在足月前对动物实施安乐死,用于不同的分析,包括液压测试。 结果: 随着程序的优化,水凝胶在70% (16/23) 的恢复胎儿和所有最后14个胎儿中保持粘附。粘附的水凝胶显示安乐死时面积的中值2倍 (IQR: 1.7-2.4) 增加,通过超声和组织学证实了缺陷覆盖。修复失败的中位最大压力为15 mmhg (IQR: 7.8-55.3),超过报告的新生儿脑脊液压力。 结论: 这种新型生物粘附复合材料允许藻酸盐-聚丙烯酰胺水凝胶选择性、稳定地附着于胎兔模型中脊柱裂缺损的特定区域,而水凝胶随着缺损随着时间的推移而膨胀。它可能成为脊柱裂和可能的其他先天性异常的产前修复的一个有价值的替代方案。 研究类型: N/A (动物和实验室研究)。 证据级别: N/A (动物和实验室研究)。

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