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The effect of diet-induced obesity and pasture on blood pressure and serum cortisol in Standardbred mares.

饮食诱导的肥胖和牧场对标准母马血压和血清皮质醇的影响。

  • 影响因子:1.86
  • DOI:10.1111/evj.13294
  • 作者列表:"Nostell K","Lindåse S","Winqvist E","Bröjer J
  • 发表时间:2021-05-01
Abstract

BACKGROUND:Obesity is associated with insulin resistance, vascular dysfunction and altered cortisol metabolism both in humans and in horses. OBJECTIVES:Evaluate the effect of weight gain induced by a haylage diet low in nonstructural carbohydrates (NSC) on insulin sensitivity, blood pressure and serum cortisol concentrations. STUDY DESIGN:In vivo experiment. METHODS:Nine adult Standardbred mares fed a fat supplemented haylage diet at 250% of the horses' daily metabolisable energy requirements for 22 weeks. Horses were then turned out on pasture for 4 weeks. Insulin sensitivity (SICLAMP ) was measured before and after weight gain and after 4 weeks of pasture using the euglycemic hyperinsulinaemic clamp (EHC) method. Body condition score (BCS), blood pressure and serum cortisol were monitored throughout the study. All data were analysed using the linear mixed model procedure. Values of P < 0.05 were considered as statistically different. RESULTS:All horses became obese during the weight gain period (BCS> 7). Mean arterial blood pressure (MAP) increased during the weight gain period and was significantly higher than initial values at the end of the weight gain period (78 ± 3 mm Hg vs 92 ± 3 mmHg). MAP remained increased on pasture (93 ± 3 mmHg). SICLAMP was unaffected by weight gain 0.9 ± 0.1 vs 1.0 ± 0.1 ([mg/kg/min × 103 ]/[µIU/mL × mmol/L])) but improved after pasture (1.6 ± 0.1 ([mg/kg/min × 103 ]/ [mU/L]). Serum cortisol concentrations increased during the weight gain period (80 ± 9 nmol/L vs 112 ± 9 nmol/L) and remained increased during pasture. MAIN LIMITATIONS:Limited number of horses and no control group. CONCLUSIONS:Obesity was associated with a linear increase in blood pressure and an increase in serum cortisol that was not associated with insulin sensitivity.

摘要

背景: 肥胖与人和马的胰岛素抵抗、血管功能障碍和皮质醇代谢改变有关。 目的: 评估低非结构碳水化合物 (NSC) 海拉格饮食诱导的体重增加对胰岛素敏感性、血压和血清皮质醇浓度的影响。 研究设计: 体内实验。 方法: 9只成年标准母马以马匹每日可代谢能量需求的250% 喂养脂肪补充海拉格饮食22周。然后将马放在牧场上4周。使用正常血糖高胰岛素钳夹 (EHC) 方法在体重增加之前和之后以及在牧场4周之后测量胰岛素敏感性 (SICLAMP)。在整个研究中监测身体状况评分 (BCS) 、血压和血清皮质醇。使用线性混合模型程序分析所有数据。P <0.05的值被认为是统计学上不同的。 结果: 所有的马在体重增加期间变得肥胖 (BCS> 7)。平均动脉血压 (MAP) 在体重增加期间增加,并且在体重增加期间结束时显著高于初始值 (78 ± 3毫米mmHg vs 92 ± 3 mmHg)。MAP在牧草上保持增加 (93 ± 3 mmHg)。SICLAMP不受体重增加的影响0.9 ± 0.1 vs 1.0 ± 0.1 ([mg/kg/min × 103 ]/[µ iu/mL × mmol/L]) 但改良后牧草 (1.6 ± 0.1 ([mg/kg/min × 103 ]/ [mU/L])。血清皮质醇浓度在增重期间增加 (80 ± 9 nmol/L vs 112 ± 9 nmol/L),并且在牧草期间保持增加。 主要限制: 有限数量的马和没有对照组。 结论: 肥胖与血压线性升高和血清皮质醇升高相关,而与胰岛素敏感性无关。

关键词: EHC 血压 皮质醇 肥胖
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