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Impact of a prior history of cancer on prognosis after myeloablative single-unit cord blood transplantation.
既往癌症史对清髓性单单位脐血移植后预后的影响。
- 影响因子:0
- DOI:10.1093/jjco/hyaa250
- 作者列表:"Okabe M","Konuma T","Oiwa-Monna M","Kato S","Isobe M","Takahashi S","Tojo A
- 发表时间:2021-04-01
Abstract
:A prior history of cancer was associated with higher non-relapse mortality or overall mortality in patients undergoing allogeneic haematopoietic cell transplantation. Because it is unclear whether the outcomes after cord blood transplantation are influenced by a prior history of cancer, we retrospectively assessed the prevalence and prognostic impact of a prior history of cancer in adult patients undergoing myeloablative single-unit cord blood transplantation in our institute between 2004 and 2020. The univariate analysis showed that a prior history of cancer did not affect the probability of overall survival; the cumulative incidence of relapse; or non-relapse mortality. In the multivariate analysis, prior history of cancer was not associated with overall mortality, relapse or non-relapse mortality. No patients with a prior history of cancer had experienced prior cancer relapse. A prior history of cancer was not associated with non-relapse mortality or overall mortality following single-unit cord blood transplantation.
摘要
: 在接受异基因造血细胞移植的患者中,癌症既往史与较高的非复发死亡率或总死亡率相关。由于尚不清楚脐带血移植后的结果是否受癌症既往史的影响,我们回顾性评估了2004年至2020年间在我们研究所接受清髓性单单位脐带血移植的成人患者中癌症既往史的患病率和预后影响。单因素分析显示,癌症既往史不影响总生存期的概率; 复发的累积发生率; 或非复发死亡率。在多变量分析中,癌症既往史与总死亡率、复发或非复发死亡率无关。没有既往有癌症病史的患者经历过癌症复发。癌症既往史与单单位脐血移植后的非复发死亡率或总死亡率无关。
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