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Antisaccade, a predictive marker for freezing of gait in Parkinson's disease and gait/gaze network connectivity.

抗扫视,帕金森病步态冻结和步态/注视网络连接的预测标志物。

  • 影响因子:7.52
  • DOI:10.1093/brain/awaa407
  • 作者列表:"Gallea C","Wicki B","Ewenczyk C","Rivaud-Péchoux S","Yahia-Cherif L","Pouget P","Vidailhet M","Hainque E
  • 发表时间:2021-03-03
Abstract

:Freezing of gait is a challenging sign of Parkinson's disease associated with disease severity and progression and involving the mesencephalic locomotor region. No predictive factor of freezing has been reported so far. The primary objective of this study was to identify predictors of freezing occurrence at 5 years. In addition, we tested whether functional connectivity of the mesencephalic locomotor region could explain the oculomotor factors at baseline that were predictive of freezing onset. We performed a prospective study investigating markers (parkinsonian signs, cognitive status and oculomotor recordings, with a particular focus on the antisaccade latencies) of disease progression at baseline and at 5 years. We identified two groups of patients defined by the onset of freezing at 5 years of follow-up; the 'Freezer' group was defined by the onset of freezing in the ON medication condition during follow-up (n = 17), while the 'non-Freezer' group did not (n = 8). Whole brain resting-state functional MRI was recorded at baseline to determine how antisaccade latencies were associated with connectivity of the mesencephalic locomotor region networks in patients compared to 25 age-matched healthy volunteers. Results showed that, at baseline and compared to the non-Freezer group, the Freezer group had equivalent motor or cognitive signs, but increased antisaccade latencies (P = 0.008). The 5-year course of freezing of gait was correlated with worsening antisaccade latencies (P = 0.0007). Baseline antisaccade latencies was also predictive of the freezing onset (χ2 = 0.008). Resting state connectivity of mesencephalic locomotor region networks correlated with (i) antisaccade latency differently in patients and healthy volunteers at baseline; and (ii) the further increase of antisaccade latency at 5 years. We concluded that antisaccade latency is a predictive marker of the 5-year onset of freezing of gait. Our study suggests that functional networks associated with gait and gaze control are concurrently altered during the course of the disease.

摘要

: 步态冻结是与疾病严重程度和进展相关并涉及中脑运动区域的帕金森病的挑战性体征。到目前为止,还没有关于冻结的预测因子的报道。本研究的主要目的是确定5年冷冻发生的预测因子。此外,我们测试了中脑运动区域的功能连接是否可以解释基线时预测冷冻发作的动眼因素。我们进行了一项前瞻性研究,调查基线和5年时疾病进展的标志物 (帕金森病体征、认知状态和眼球运动记录,特别关注抗扫视潜伏期)。我们确定了两组患者,定义为在5年随访时开始冷冻; “冻结” 组定义为在随访期间药物治疗条件下开始冷冻 (n   =   17),而 “非freezer” 组没有 (n   =   8)。在基线时记录全脑静息态功能MRI,以确定与25名年龄匹配的健康志愿者相比,患者的反扫视潜伏期与中脑运动区域网络的连通性之间的关联。结果显示,在基线时,与非冷冻组相比,冷冻组具有等同的运动或认知体征,但增加了抗扫视潜伏期 (p   =   0.008)。步态冻结的5年病程与抗扫视潜伏期恶化相关 (p   =   0.0007)。基线抗扫视潜伏期也可预测冻结开始 (χ2 2 = 0.008)。中脑运动区域网络的静息状态连通性与 (i) 基线时患者和健康志愿者的抗扫视潜伏期不同; (ii) 抗扫视潜伏期在5年时进一步增加。我们得出结论,反扫视潜伏期是步态冻结5年发作的预测指标。我们的研究表明,与步态和注视控制相关的功能网络在疾病过程中同时改变。

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DOI:10.1007/s11033-021-06299-9
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