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Effect of infrared and red monochromatic light on equine wound healing.

红外光和红光单色光对马创面愈合的影响。

  • 影响因子:1.86
  • DOI:10.1111/evj.13266
  • 作者列表:"Michanek P","Toth T","Bergström E","Treffenberg-Pettersson H","Bergh A
  • 发表时间:2021-01-01
Abstract

BACKGROUND:Light-emitting diodes (LEDs) are commonly used for treating a variety of disorders in horses, including wounds. Despite its claim to shorten healing times, there is a lack of scientific documentation regarding its effects. OBJECTIVES:To investigate if treatment with pulsating visible red light (λ ≈ 637 nm) and near-infrared (NIR) light (λ ≈ 956 nm) affects wound healing. STUDY DESIGN:Randomised blinded controlled experimental study. METHODS:A circular skin wound (Ø = 2 cm) was created on each side of the neck in eight healthy horses. One randomly chosen wound received light treatment and the other served as an untreated control. Treatment duration was 4 minutes and 40 seconds (red light 95 seconds, 2.3 mW/cm2 ; NIR light 185 seconds, 6.4 mW/cm2 ) and was performed once daily on day 0-4, 7-11, 14-18 and 21-25. The wounds were photographed and evaluated using digital photoplanimetry on day 0, 1, 2, 3, 4, 7, 14, 21, 28 and 35. The degree of swelling was assessed with diagnostic ultrasound on the same days except the last recording was performed on day 36 instead of 35. Days to total healing was recorded. ANOVA was used for statistical analysis (P < .05). RESULTS:The wound area (P = .2-.9) and degree of swelling (P = .2-1.0) did not differ between treated and control groups on any day. There was a significant difference (P = .03) in healing time between control (49.0, 95% CI = 35.4-62.6 days) and treated wounds (51.8, 95% CI = 38.7-64.8 days). MAIN LIMITATIONS:The wounds were treated until day 25 and this study does not investigate the effect of a longer treatment period than 25 days. CONCLUSIONS:The results of this study do not indicate any clinically relevant positive effect of pulsating visible red light and NIR light on the healing of experimental skin wounds in horses, compared with no treatment.

摘要

背景: 发光二极管 (led) 通常用于治疗马的各种疾病,包括伤口。尽管它声称缩短愈合时间,但缺乏关于其效果的科学文献。 目的: 研究脉冲可见红光 (λ ≈ 637 nm) 和近红外 (NIR) 光 (λ ≈ 956 nm) 治疗是否影响伤口愈合。 研究设计: 随机盲法对照实验研究。 方法: 在八匹健康马的颈部每侧产生圆形皮肤伤口 (Ø = 2厘米)。一个随机选择的伤口接受光处理,另一个作为未处理的对照。处理持续时间为4分40秒 (红光95秒,2.3 mW/cm2; NIR光185秒,6.4 mW/cm2),并且在第0-4、7-11、14-18和21-25天每天进行一次。在第0、1、2、3、4、7、14、21、28和35天,对伤口进行拍照和评估。除了在第36天而不是第35天进行最后记录之外,在相同的日子用诊断超声评估肿胀程度。记录至完全愈合的天数。使用ANOVA进行统计学分析 (P <.05)。 结果: 治疗组和对照组在任何一天的伤口面积 (P = .2-.9) 和肿胀程度 (P = .2-1.0) 没有差异。对照组 (.03,49.0 CI = 95%-35.4天) 和处理伤口 (62.6,51.8 CI = 95%-38.7天) 之间的愈合时间存在显著差异 (P = 64.8)。 主要限制: 伤口治疗至第25天,并且本研究不调查超过25天的更长治疗期的效果。 结论: 与未治疗相比,本研究的结果没有表明脉动可见红光和NIR光对马的实验性皮肤伤口愈合的任何临床相关的积极影响。

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发表时间:2021-02-01
DOI:10.1080/14656566.2020.1814255
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DOI:10.1007/s11033-021-06299-9
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