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Hypoxia in multiple sclerosis; is it the chicken or the egg?

多发性硬化症中的缺氧; 是鸡还是蛋?

  • 影响因子:7.52
  • DOI:10.1093/brain/awaa427
  • 作者列表:"Halder SK","Milner R
  • 发表时间:2021-03-03
Abstract

:Over the past 50 years, intense research effort has taught us a great deal about multiple sclerosis. We know that it is the most common neurological disease affecting the young-middle aged, that it affects two to three times more females than males, and that it is characterized as an autoimmune disease, in which autoreactive T lymphocytes cross the blood-brain barrier, resulting in demyelinating lesions. But despite all the knowledge gained, a key question still remains; what is the initial event that triggers the inflammatory demyelinating process? While most research effort to date has focused on the immune system, more recently, another potential candidate has emerged: hypoxia. Specifically, a growing number of studies have described the presence of hypoxia (both 'virtual' and real) at an early stage of demyelinating lesions, and several groups, including our own, have begun to investigate how manipulation of inspired oxygen levels impacts disease progression. In this review we summarize the findings of these hypoxia studies, and in particular, address three main questions: (i) is the hypoxia found in demyelinating lesions 'virtual' or real; (ii) what causes this hypoxia; and (iii) how does manipulation of inspired oxygen impact disease progression?

摘要

: 在过去的50年里,紧张的研究努力教会了我们很多关于多发性硬化症的知识。我们知道它是影响青壮年最常见的神经系统疾病,它影响的女性比男性多2-3倍,它的特征是自身免疫性疾病,自身反应性T淋巴细胞穿过血脑屏障,导致脱髓鞘病变。但是,尽管获得了所有知识,一个关键问题仍然存在; 触发炎性脱髓鞘过程的初始事件是什么?虽然迄今为止大多数研究工作都集中在免疫系统上,但最近又出现了另一个潜在的候选者: 缺氧。具体而言,越来越多的研究已经描述了在脱髓鞘病变的早期阶段存在缺氧 (“虚拟” 和真实的),并且包括我们自己的几个小组已经开始研究调节吸入氧水平如何影响疾病进展。在这篇综述中,我们总结了这些缺氧研究的发现,特别是解决了三个主要问题 :( i) 在脱髓鞘病变中发现的缺氧是 “虚拟的” 还是真实的; (ii) 是什么导致了这种缺氧; 以及 (iii) 吸入氧的操作如何影响疾病进展?

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DOI:10.1080/14656566.2020.1814255
作者列表:["Sawada H","Oeda T","Kohsaka M","Tomita S","Umemura A","Park K","Yamamoto K","Kiyohara K"]

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发表时间:2021-03-24
DOI:10.1007/s11033-021-06299-9
作者列表:["Louvrier A","Terranova L","Meyer C","Meyer F","Euvrard E","Kroemer M","Rolin G"]

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