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Abnormal dorsal attention network activation in memory impairment after traumatic brain injury.

创伤性脑损伤后记忆障碍中的背侧注意网络异常激活。

  • 影响因子:7.52
  • DOI:10.1093/brain/awaa380
  • 作者列表:"Mallas EJ","De Simoni S","Scott G","Jolly AE","Hampshire A","Li LM","Bourke NJ","Roberts SAG","Gorgoraptis N","Sharp DJ
  • 发表时间:2021-02-12
Abstract

:Memory impairment is a common, disabling effect of traumatic brain injury. In healthy individuals, successful memory encoding is associated with activation of the dorsal attention network as well as suppression of the default mode network. Here, in traumatic brain injury patients we examined whether: (i) impairments in memory encoding are associated with abnormal brain activation in these networks; (ii) whether changes in this brain activity predict subsequent memory retrieval; and (iii) whether abnormal white matter integrity underpinning functional networks is associated with impaired subsequent memory. Thirty-five patients with moderate-severe traumatic brain injury aged 23-65 years (74% males) in the post-acute/chronic phase after injury and 16 healthy control subjects underwent functional MRI during performance of an abstract image memory encoding task. Diffusion tensor imaging was used to assess structural abnormalities across patient groups compared to 28 age-matched healthy controls. Successful memory encoding across all participants was associated with activation of the dorsal attention network, the ventral visual stream and medial temporal lobes. Decreased activation was seen in the default mode network. Patients with preserved episodic memory demonstrated increased activation in areas of the dorsal attention network. Patients with impaired memory showed increased left anterior prefrontal activity. White matter microstructure underpinning connectivity between core nodes of the encoding networks was significantly reduced in patients with memory impairment. Our results show for the first time that patients with impaired episodic memory show abnormal activation of key nodes within the dorsal attention network and regions regulating default mode network activity during encoding. Successful encoding was associated with an opposite direction of signal change between patients with and without memory impairment, suggesting that memory encoding mechanisms could be fundamentally altered in this population. We demonstrate a clear relationship between functional networks activated during encoding and underlying abnormalities within the structural connectome in patients with memory impairment. We suggest that encoding failures in this group are likely due to failed control of goal-directed attentional resources.

摘要

: 记忆障碍是创伤性脑损伤常见的致残作用。在健康个体中,成功的记忆编码与背侧注意网络的激活以及默认模式网络的抑制相关联。在这里,在创伤性脑损伤患者中,我们检查了是否 :( i) 记忆编码的损伤与这些网络中的异常脑激活相关; (ii) 这种脑活动的变化是否预测随后的记忆检索; 和 (iii) 支持功能网络的白质完整性异常是否与后续记忆受损有关。35名年龄在23-65岁的中重度创伤性脑损伤患者 (74% 名男性) 在损伤后急性/慢性期和16名健康对照受试者在执行抽象图像记忆编码任务期间接受了功能性MRI。与28个年龄匹配的健康对照相比,扩散张量成像用于评估患者组的结构异常。所有参与者的成功记忆编码与背侧注意网络、腹侧视觉流和内侧颞叶的激活相关。在默认模式网络中看到激活减少。保留情景记忆的患者表现出背侧注意网络区域的激活增加。患者的记忆障碍增高左前额活动.脑白质微结构支撑之间的连接的核心节点的编码网络明显降低患者的记忆障碍.我们的结果首次显示,情景记忆受损的患者在编码过程中表现出背侧注意网络和调节默认模式网络活动的区域内关键节点的异常激活。成功的编码与有记忆障碍和无记忆障碍的患者之间的相反方向的信号变化相关,这表明在该人群中记忆编码机制可以从根本上改变。我们证明了记忆障碍患者在编码过程中激活的功能网络与结构连接体内潜在异常之间的明确关系。我们认为,这组编码失败可能是由于目标导向注意力资源控制失败。

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