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The relationship between urinary C-Telopeptide fragments of type II collagen, knee joint load, pain, and physical function in individuals with medial knee osteoarthritis.

内侧膝骨关节炎个体尿II型胶原C端肽片段与膝关节负荷、疼痛和身体功能的关系。

  • 影响因子:2.16
  • DOI:10.1016/j.bjpt.2020.02.002
  • 作者列表:"Selistre LFA","Gonçalves GH","Vasilceac FA","Serrão PRMDS","Nakagawa TH","Petrella M","Jones RK","Mattiello SM
  • 发表时间:2021-01-01
Abstract

OBJECTIVE:Considering the osteoarthritis (OA) model that integrates the biological, mechanical, and structural components of the disease, the present study aimed to investigate the association between urinary C-Telopeptide fragments of type II collagen (uCTX-II), knee joint moments, pain, and physical function in individuals with medial knee OA. METHODS:Twenty-five subjects radiographically diagnosed with knee OA were recruited. Participants were evaluated through three-dimensional gait analysis, uCTX-II level, the WOMAC pain and physical function scores, and the 40m walk test. The association between these variables was investigated using Pearson's product-moment correlation, followed by a hierarchical linear regression, controlled by OA severity and body mass index (BMI). RESULTS:No relationship was found between uCTX-II level and knee moments. A significant correlation between uCTX-II level and pain, physical function, and the 40m walk test was found. The hierarchical linear regression controlling for OA severity and BMI showed that uCTX-II level explained 9% of the WOMAC pain score, 27% of the WOMAC physical function score, and 7% of the 40m walk test. CONCLUSION:Greater uCTX-II level is associated with higher pain and reduced physical function and 40m walk test performance in individuals with medial knee OA.

摘要

目的: 考虑到骨关节炎 (OA) 模型整合了疾病的生物、机械和结构成分,本研究旨在探讨II型胶原 (uctx-ii) 的尿C端肽片段、膝关节力矩、疼痛之间的关联,和膝关节内侧OA个体的身体功能。 方法: 招募了25名经x线检查诊断为膝关节OA的受试者。通过三维步态分析、uctx-ii水平、WOMAC疼痛和身体功能评分以及40m步行测试对参与者进行评估。这些变量之间的关联使用Pearson的乘积-矩相关性进行研究,然后通过由OA严重程度和体重指数 (BMI) 控制的分层线性回归。 结果: 未发现uctx-ii水平与膝关节力矩之间的关系。发现uctx-ii水平与疼痛、身体功能和40m步行试验之间存在显著相关性。控制OA严重程度和BMI的分层线性回归显示,uctx-ii水平解释了9% 的WOMAC疼痛评分,27% 的WOMAC身体功能评分和7% 的40m步行测试。 结论: 在内侧膝OA个体中,较高的uctx-ii水平与较高的疼痛、降低的身体功能和40m步行试验表现相关。

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