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Impact of the Number of Cores on the Prostate Cancer Detection Rate in Men Undergoing in-Bore Magnetic Resonance Imaging-Guided Targeted Biopsies.

核心数量对接受钻孔磁共振成像引导靶向活检的男性前列腺癌检出率的影响。

  • 影响因子:1.48
  • DOI:10.1097/RCT.0000000000001115
  • 作者列表:"Subramanian N","Recchimuzzi DZ","Xi Y","Diaz de Leon A","Chen H","Xie D","Goldberg K","Rofsky NM","Pedrosa I","Costa DN
  • 发表时间:2021-03-01
Abstract

OBJECTIVE:To determine the incremental detection rate of clinically significant prostate cancer (csPCa) provided by sequential cores during in-bore magnetic resonance imaging (MRI)-guided prostate biopsies. METHODS:Single-center, retrospective interpretation of prospectively acquired data in men without previous diagnosis of csPCa who underwent in-bore MRI-guided prostate biopsy between May 2017 and December 2019. Endpoints included detection of csPCa (grade group [GG] ≥ 2) and rate of GG upgrade provided by additional cores. Descriptive statistics presented as mean and standard deviation for the continuous variables, and frequency and percentage for the categorical variables. RESULTS:Four hundred and forty-three men with 747 lesions met eligibility criteria. Clinically significant prostate cancer was detected in 43.1% (322/747) of the biopsied lesions and GG 2 PCa or greater was identified by the first core in 78.3% (252/322) of them. On a per-core basis, cores 2, 3, 4, and 5 found new csPCa in 6% (42/744), 4% (26/719), 1% (2/137), and 0% (0/11) of the cases. Core biopsy 2, 3, 4, and 5 resulted in GG upgrade in 12% (91/744), 7% (49/719), 7% (9/137), and 0% (0/11) of the lesions, respectively. Each additional core was associated with a mean increase of 5 minutes in the duration of the biopsy. CONCLUSIONS:In men undergoing in-bore MRI-guided prostate biopsies, 3 targeted cores per lesion provide an optimal trade-off between detection of clinically significant tumors and biopsy duration.

摘要

目的: 确定在钻孔内磁共振成像 (MRI) 引导下前列腺活检中,序贯核心提供的临床显著前列腺癌 (csPCa) 的增量检出率。 方法: 单中心,回顾性分析2017年5月至2019年12月间接受MRI引导下前列腺活检的既往无csPCa诊断的男性患者的前瞻性数据。终点包括检测csPCa (grade group [GG] ≥ 2) 和额外核心提供的GG升级率。描述性统计表示为连续变量的平均值和标准差,分类变量的频率和百分比。 结果: 747名个病灶的男性符合入选标准。在43.1% (322/747) 的活检病变中检测到临床显著的前列腺癌,并且在其中78.3% (252/322) 的第一核心中鉴定出GG 2 PCa或更高。在每个核心的基础上,核心2、3、4和5在6% (42/744) 、4% (26/719) 、1% (2/137) 和0% (0/11) 的病例中发现了新的csPCa。核心活检2、3、4和5分别在12% (91/744) 、7% (49/719) 、7% (9/137) 和0% (0/11) 的病变中导致GG升级。每个额外的核心与活检持续时间的平均增加5分钟相关。 结论: 在接受钻孔MRI引导下前列腺活检的男性中,每个病灶3个靶向核心提供了临床显著肿瘤检测和活检持续时间之间的最佳权衡。

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