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Geometric Distortion Correction of Renal Diffusion Tensor Imaging Using the Reversed Gradient Method.

采用反向梯度法校正肾脏扩散张量成像的几何失真。

  • 影响因子:1.48
  • DOI:10.1097/RCT.0000000000001124
  • 作者列表:"Lim RP","Lim JC","Teruel JR","Botterill E","Seah JM","Farquharson S","Ekinci EI","Sigmund EE
  • 发表时间:2021-03-01
Abstract

ABSTRACT:Renal echo planar diffusion tensor imaging (DTI) has clinical potential but suffers from geometric distortion. We evaluated feasibility of reversed gradient distortion correction in 10 diabetic patients and 6 volunteers. Renal area, apparent diffusion coefficient, fractional anisotropy, and tensor eigenvalues were measured on uncorrected and distortion-corrected DTI. Corrected DTI correlated better than uncorrected DTI (r = 0.904 vs 0.840, P = 0.002) with reference anatomic T2-weighted imaging, with no significant difference in DTI metrics.

摘要

摘要: 肾回声平面弥散张量成像 (DTI) 具有潜在的临床应用价值,但存在几何畸变。我们在10名糖尿病患者和6名志愿者中评估了反向梯度失真校正的可行性。在未校正和畸变校正的DTI上测量肾面积、表观扩散系数、各向异性分数和张量特征值。校正后的DTI与参考解剖T2-weighted成像的相关性优于未校正的DTI (r = 0.904 vs 0.840,P = 0.002),DTI指标无显著差异。

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发表时间:2021-02-01
DOI:10.1007/s11033-021-06155-w
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影响因子:2.68
发表时间:2021-02-01
DOI:10.1080/14656566.2020.1814255
作者列表:["Sawada H","Oeda T","Kohsaka M","Tomita S","Umemura A","Park K","Yamamoto K","Kiyohara K"]

METHODS:BACKGROUND:Cholinergic neurotransmission regulates neuroinflammation in Parkinson disease (PD). RESEARCH DESIGN AND METHODS:The authors conducted a delayed-start study of donepezil for cognitive decline in non-demented PD patients. The study consisted of a 96-week randomized placebo-controlled double-blind phase 1, followed by a 24-week donepezil extension phase 2. The primary outcome measure was a change in the Mini-Mental State Examination (MMSE) at week 120. RESULTS:A total of 98 patients were randomly allocated to the early-start (donepezil-to-donepezil) and delayed-start (placebo-to-donepezil) groups. Mean (SD) of the baseline MMSE was 27.6 (2.0) and 28.0 (2.1), respectively. MMSE change at week 120 was better in the early-start group than in the delayed-start group, but the difference was not significant. The MMSE declined in apolipoprotein ε4 carriers, but not in non-carriers, and the factor interaction (intervention × ε4 genotype) was highly significant (P < 0.001). Analyzed with the interaction, the difference was significant (group difference 1.95 [0.33 to 3.57], P = 0.018). The MMSE decline slope in phase 1 was significantly better in the early-start group than in the delayed-start group (P = 0.048). CONCLUSIONS:Cognitive function deteriorated in ε4 carriers, but not in non-carriers, and early-start donepezil may postpone cognitive decline in the former.

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影响因子:2.06
发表时间:2021-03-24
DOI:10.1007/s11033-021-06299-9
作者列表:["Louvrier A","Terranova L","Meyer C","Meyer F","Euvrard E","Kroemer M","Rolin G"]

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