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Quantitative Analysis of Mobile Proteins in Normal Brain Tissue by Amide Proton Transfer Imaging: Age Dependence and Sex Differences.

通过酰胺质子转移成像定量分析正常脑组织中的移动蛋白: 年龄依赖性和性别差异。

  • 影响因子:1.48
  • DOI:10.1097/RCT.0000000000001141
  • 作者列表:"Sugawara K","Miyati T","Ueda R","Yoshimaru D","Nakamura M","Komatsu S","Hagiwara K","Saigusa K
  • 发表时间:2021-03-01
Abstract

PURPOSE:The aims of this study were to evaluate the relationship between age change and amide proton transfer (APT) signal in each region of the whole brain and to derive the standard value of APT signal in each brain region of normal adults. MATERIALS AND METHODS:Using the mDIXON 3-dimensional-APT sequence of the fast spin echo method, an APT image was obtained. In total, 60 patients (mean age, 49.8 ± 16.9 years) with no abnormal findings on magnetic resonance imaging data were included. For image analysis, registration parameters were created using the FMRIB Software Library 5.0.11, and then a region of interest was set in the Montreal Neurological Institute structural atlas for analysis. Statistical analyses were performed using the age-dependent and sex differences in APT signals from each brain region. RESULTS:No significant correlation was seen between APT signal and age and sex in all brain regions. CONCLUSION:Under the APT imaging parameter conditions used in this study, local brain APT signals in healthy adults are independent of age and sex.

摘要

目的: 本研究的目的是评估年龄变化与全脑各区域中酰胺质子转移 (APT) 信号之间的关系,并得出正常成人各脑区域中APT信号的标准值。 材料与方法: 利用快速自旋回波法的mDIXON 3维-APT序列,获得APT图像。总共纳入60例患者 (平均年龄,49.8 ± 16.9岁),磁共振成像数据无异常发现。对于图像分析,使用FMRIB软件库5.0.11创建配准参数,然后在蒙特利尔神经学研究所结构图谱中设置感兴趣区域用于分析。使用来自每个脑区域的APT信号的年龄依赖性和性别差异进行统计分析。 结果: 全脑区APT信号与年龄、性别无明显相关性。 结论: 在本研究使用的APT成像参数条件下,健康成人的局部脑APT信号与年龄和性别无关。

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