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Importance of Thalamostriatal Pathway Associated With Neurocognitive Dysfunctions in Children With Neurofibromatosis Type 1: Diffusion Tensor Imaging Findings.

1型神经纤维瘤病患儿丘脑纹状体通路与神经认知功能障碍相关的重要性: 弥散张量成像表现。

  • 影响因子:1.48
  • DOI:10.1097/RCT.0000000000001134
  • 作者列表:"Cesme DH","Aydin S","Alkan A","Gultekin MA","Peker AA","Toprak MF","Iscan A
  • 发表时间:2021-03-01
Abstract

OBJECTIVE:To determine whether there is a difference between healthy control group and children with neurofibromatosis type 1 (NF1) in terms of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values in different regions of the brain associated with neurocognitive functions and to investigate the correlation between diffusion tensor imaging parameters and neurocognitive dysfunctions. METHODS:The study included 28 children with NF1 and 21 controls. Nine distinct areas related to cognitive functions were selected for the analysis. The ADC and FA values were compared. RESULTS:There was a significant difference between NF1 and healthy control in terms of ADC values obtained from all areas. The ADC values at obtained from thalamus and striatum were positively correlated with the full-scale intelligence quotient (IQ), verbal IQ, and performance IQ. CONCLUSIONS:We are speculated that the development of microstructural damage in the thalamostriatal pathway may lead to neurocognitive dysfunction.

摘要

目的: 确定健康对照组和1型神经纤维瘤病 (NF1) 患儿在表观扩散系数 (ADC) 和部分各向异性 (FA) 方面是否存在差异。与神经认知功能相关的脑不同区域的值,并研究扩散张量成像参数与神经认知功能障碍之间的相关性。 方法: 本研究包括28名NF1儿童和21名对照。选择与认知功能相关的九个不同区域进行分析。比较ADC和FA值。 结果: 从所有区域获得的ADC值而言,NF1与健康对照之间存在显著差异。从丘脑和纹状体获得的ADC值与全量表智商 (IQ) 、语言智商和性能智商呈正相关。 结论: 我们推测丘脑纹状体通路的微结构损伤可能导致神经认知功能障碍。

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DOI:10.1007/s11033-021-06155-w
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影响因子:2.68
发表时间:2021-02-01
DOI:10.1080/14656566.2020.1814255
作者列表:["Sawada H","Oeda T","Kohsaka M","Tomita S","Umemura A","Park K","Yamamoto K","Kiyohara K"]

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发表时间:2021-03-24
DOI:10.1007/s11033-021-06299-9
作者列表:["Louvrier A","Terranova L","Meyer C","Meyer F","Euvrard E","Kroemer M","Rolin G"]

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