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A multivariate analysis of the association between corticostriatal functional connectivity and psychosis-like experiences in the general community.

一般社区中皮质纹状体功能连接与精神病样经历之间关联的多变量分析。

  • 影响因子:2.70
  • DOI:10.1016/j.pscychresns.2020.111202
  • 作者列表:"Pani SM","Sabaroedin K","Tiego J","Bellgrove MA","Fornito A
  • 发表时间:2021-01-30
Abstract

:Dysfunction of dorsal corticostriatal (CST) circuitry is thought to play an important role in psychosis. Here, we use multivariate analysis to characterize covariance between CST functional connectivity and psychosis-like experiences (PLEs) in non-clinical individuals. In 353 healthy adults (155 males), we use partial least squares (PLS) to identify latent variables (LV) describing covariance between seven PLE questionnaire measures and functional connectivity estimated between each of six striatal seed regions and the rest of the brain using multiband resting-state fMRI. Hypothesis-driven PLS of the dorsal caudate (DC) seed identified one significant LV, accounting for 23.88% of covariance, with loadings from nearly all PLE subscales. Cortical regions implicated in this LV comprise anterior cingulate and left dorsolateral prefrontal cortex. Lower connectivity between these cortical areas and the DC seed was associated with more severe PLEs. Using multivariate modeling, we identified an association between dorsal CST connectivity and PLEs in the general community that implicates similar brain regions to those identified in patient groups. Our results highlight that the severity of both positive/negative symptom-like PLEs is related with functional coupling between the DC and dorsolateral PFC, suggesting this neural circuit may play a role in mediating risk for general psychosis-related psychopathology.

摘要

: 背侧皮质纹状体 (CST) 回路的功能障碍被认为在精神病中起重要作用。在这里,我们使用多变量分析来表征非临床个体中CST功能连接和精神病样经历 (PLEs) 之间的协方差。在353名健康成年人 (155名男性) 中,我们使用偏最小二乘法 (PLS) 来识别潜在变量 (LV),描述使用多频带静息态fMRI在六个纹状体种子区域和大脑其余部分之间估计的七个问卷测量和功能连接之间的协方差。背侧尾状核 (DC) 种子的假设驱动PLS鉴定了一个显著的LV,占协方差的23.88%,载荷来自几乎所有PLE分量表。涉及该LV的皮质区域包括前扣带和左背外侧前额叶皮质。这些皮质区域和DC种子之间的较低连接性与更严重的PLEs相关。使用多变量建模,我们在一般社区中确定了背CST连通性和PLEs之间的关联,这与患者组中确定的脑区域相似。我们的研究结果强调,阳性/阴性症状样样本的严重程度与DC和背外侧PFC之间的功能耦合有关,表明这种神经回路可能在介导一般精神病相关精神病理学的风险中起作用。

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