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Alterations of Cerebral Blood Flow Network in Behavioral Variant Frontotemporal Dementia patients with and without Apathy.

行为变异额颞叶痴呆伴和不伴情感淡漠患者脑血流网络的改变。

  • 影响因子:2.70
  • DOI:10.1016/j.pscychresns.2020.111203
  • 作者列表:"Zhou Z","Zheng X","Li R","Zheng Y","Jin Y","Jia S","Peng D","Jiao J
  • 发表时间:2021-01-30
Abstract

:Apathy is one of the core symptoms in behavioral variant of frontotemporal dementia (bvFTD), and increases patient's morbidity and caregiver's distress. In this study, we applied a graph theoretical analysis (GTA) to analyze the topological properties of cerebral blood flow (CBF) network in 64 bvFTD patients with and without apathy (47 bvFTD-apathy and 17 bvFTD-woapathy, respectively), and 20 normal controls (NCs) based on single photon emission tomography (SPECT). Compared with the NCs, both the bvFTD groups preserved global function and typical features of small-worldness, but exhibited the loss of hubs mainly distributed in the prefrontal cortex (PFC). Compared with bvFTD-woapathy, the bvFTD-apathy group exhibited additional loss of hubs in the ventral PFC areas, middle cingulate cortex, limbic and paralimbic system, and subcortical regions, but recruited hubs in the areas of angular gyrus, precuneus and posterior cingulate cortex. Overall, our findings support the hypothesis that the disruption of frontostriatal circuit is associated with apathy in bvFTD.

摘要

: 情感淡漠是额颞叶痴呆 (bvFTD) 行为变异的核心症状之一,并增加患者的发病率和照顾者的痛苦。在这项研究中,我们应用图形理论分析 (GTA) 来分析64个患有和不患有情感淡漠的bvFTD患者 (分别为47个bvFTD-情感淡漠和17个bvFTD-woapathy) 和20个正常对照 (NCs) 的脑血流 (CBF) 网络的拓扑特性。基于单光子发射断层成像 (SPECT)。与NCs相比,bvFTD组保留了全局功能和典型的小世界特征,但表现出主要分布在前额叶皮层 (PFC) 的中枢缺失。与bvFTD-woapathy相比,bvFTD-athy组在腹侧PFC区域、中扣带皮层、边缘和副营养系统以及皮层下区域表现出更多的中枢缺失,但在角回、前叶和后扣带皮层区域招募中枢。总的来说,我们的发现支持了这样的假设,即额纹状体回路的破坏与bvFTD中的淡漠相关。

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