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Higher volumes of hippocampal subfields in pediatric obsessive-compulsive disorder.

小儿强迫症海马亚野体积较高。

  • 影响因子:2.70
  • DOI:10.1016/j.pscychresns.2020.111200
  • 作者列表:"Vattimo EFQ","Dos Santos AC","Hoexter MQ","Frudit P","Miguel EC","Shavitt RG","Batistuzzo MC
  • 发表时间:2021-01-30
Abstract

:Differences in hippocampus volume have been identified in adult patients with obsessive-compulsive disorder (OCD). However, the role of this limbic structure in pediatric patients is unclear. This study aimed to investigate the hippocampus and its subregions in a sample of 29 children and adolescents with OCD compared to 28 healthy controls, matched for age, sex, education, and IQ. Volumetric segmentation was performed using the Freesurfer software to calculate the volumes of the subregions that reflect the hippocampal cytoarchitecture. The volumes of three anatomic subregions (tail, body, and head) were also calculated. ANCOVA was performed to investigate differences of these volumes between patients and controls, controlling for total gray matter volume. After Bonferroni correction for multiple comparisons (p-value < 0.00556 for the body and < 0.00625 for the head structures), patients presented statistically significant larger volumes of the following structures: left subiculum body; left CA4 body; left GC-DG body; left molecular layer body; right parasubiculum; left CA4 head; left molecular layer head; right subiculum head and right molecular layer head. These enlarged volumes resulted in larger left and right whole hippocampi in patients, as well as bilateral hippocampal heads and left hippocampal body (all p-values < 0.00625). There were no associations between OCD severity and hippocampal volumes. These findings diverge from previous reports on adults and may indicate that larger hippocampal volumes could reflect an early marker of OCD, not present in adults.

摘要

: 在患有强迫症 (OCD) 的成年患者中已经确定了海马体积的差异。然而,这种边缘结构在儿科患者中的作用尚不清楚。本研究旨在调查29名强迫症儿童和青少年的海马及其亚区域,与28名健康对照相比,年龄,性别,教育和智商相匹配。使用Freesurfer软件进行体积分割,以计算反映海马细胞结构的子区域的体积。还计算了三个解剖区域 (尾部、身体和头部) 的体积。进行ANCOVA以研究患者和对照之间这些体积的差异,控制总灰质体积。在对多重比较进行Bonferroni校正后 (身体的p值 <0.00556,头部结构的p值 <0.00625),患者表现出具有统计学意义的较大体积的以下结构: 左囊下体; 左CA4体; 左gc-dg体; 左分子层体; 右枕旁体; 左CA4头;左分子层头、右囊下头、右分子层头。这些扩大的体积导致患者中更大的左和右整个海马,以及双侧海马头和左海马体 (所有p值 <0.00625)。OCD严重程度与海马体积之间没有相关性。这些发现与以前关于成人的报告有所不同,可能表明较大的海马体积可以反映OCD的早期标志物,而在成人中不存在。

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