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The development of an fMRI protocol to investigate vmPFC network functioning underlying the generalization of behavioral control.

开发fMRI协议来研究行为控制泛化的vmPFC网络功能。

  • 影响因子:2.70
  • DOI:10.1016/j.pscychresns.2020.111197
  • 作者列表:"Cremers H","Keedy S","Coccaro E
  • 发表时间:2021-01-30
Abstract

:Experiencing behavioral control over stress can have long-lasting and generalizing effects. Animal research has shown that vmPFC-subcortical interactions are critical for behavioral control; however, research in humans is sparse. Therefore a paradigm was developed in which participants (n = 18) were first assigned to a controllable or uncontrollable version of a signal detection task associated with mild shocks. Subsequently, subjects underwent an fMRI task on the anticipation of speaking in public while measuring self-reported stress, heart rate, and vmPFC network topology. The signal detection task results revealed faster responses to potential shock trials and a trend difference between the controllable and uncontrollable group. The speech anticipation procedure did not show significant between-group differences on self-reported stress or heart rate. fMRI results indicated higher vmPFC efficiency in the controllable threat group at baseline and recovery but similar to the uncontrollable group during speech anticipation. The current report establishes the feasibility of the protocol. However, to evaluate the generalization effect of controllability on the behavioral, physiological, and neural levels further, adequately-powered follow-up research is needed.

摘要

: 经历对压力的行为控制可以产生持久和普遍的影响。动物研究表明,vmPFC-皮质下相互作用对行为控制至关重要; 然而,对人类的研究很少。因此,开发了一种范例,其中参与者 (n = 18) 首先被分配到与轻度冲击相关的信号检测任务的可控或不可控版本。随后,受试者在测量自我报告的压力、心率和vmPFC网络拓扑的同时,接受了关于在公共场合讲话的预期的fMRI任务。信号检测任务结果揭示了对潜在休克试验的更快反应以及可控组和不可控组之间的趋势差异。言语预测程序在自我报告的压力或心率上没有显示出显著的组间差异。fMRI结果表明,在基线和恢复时,可控威胁组的vmPFC效率较高,但与语音预期期间的不可控组相似。本报告确定了该方案的可行性。然而,为了进一步评估可控性对行为、生理和神经水平的泛化作用,需要足够有力的后续研究。

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