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Examination of structural brain changes in recent suicidal behavior.

检查近期自杀行为的脑结构变化。

  • 影响因子:2.70
  • DOI:10.1016/j.pscychresns.2020.111216
  • 作者列表:"Kim DJ","Bartlett EA","DeLorenzo C","Parsey RV","Kilts C","Cáceda R
  • 发表时间:2021-01-30
Abstract

:We aimed to identify brain structural changes in cortical and subcortical regions linked to recent suicidal behavior. We performed secondary analyses of structural MRI data of two independent studies, namely the Establishing Moderators/Biosignatures of Antidepressant Response - Clinical Care (EMBARC) study and a Little Rock study on acute suicidal behavior. Study 1 (EMBARC, N = 187), compared individuals with remote suicide attempts (Remote-SA), individuals with lifetime suicide ideation but no attempts (Lifetime-SI only), and depressed individuals without lifetime suicide ideation or attempts (non-suicidal depressed). Study 2 (Little Rock data, N = 34) included patients recently hospitalized for suicide ideation or attempt constituted by: patients who recently attempted suicide (Recent-SA), individuals with remote suicide attempts (Remote-SA), and Lifetime-SI only. Study 3 combined the EMBARC and Little Rock datasets including Recent-SA, Remote-SA, Lifetime-SI only and non-suicidal depressed individuals. In Study 1 and Study 2, no significant differences were observed between groups. In Study 3, significantly lower middle temporal gyrus thickness, insular surface area, and thalamic volume and higher volume in the nucleus accumbens were observed in Recent-SA. This pattern of structural abnormalities may underlie pain and emotion dysregulation, which have been linked to the transition from suicidal thoughts to action.

摘要

: 我们旨在确定与近期自杀行为相关的皮质和皮质下区域的脑结构变化。我们对两项独立研究的结构MRI数据进行了二次分析,即抗抑郁反应-临床护理 (EMBARC) 研究的建立调节者/生物特征研究和急性自杀行为的小Rock研究。研究1 (EMBARC,N = 187),比较了有远程自杀企图 (remote-SA) 的个体、有终身自杀意念但没有企图的个体 (仅限lifetime-SI) 和没有终身自杀意念或企图的抑郁个体 (非自杀性抑郁)。研究2 (Little Rock数据,N = 34) 包括最近因自杀意念或企图而住院的患者,其构成如下: 最近试图自杀的患者 (最近-SA) 、有远程自杀企图的个体 (远程-SA) 和仅终身-SI。研究3结合了EMBARC和Little Rock数据集,包括近期-SA、远程-SA、仅终身-SI和非自杀性抑郁个体。在研究1和研究2中,未观察到组间的显著差异。在研究3中,在近期-SA中观察到显著较低的颞中回厚度、岛叶表面积和丘脑体积以及较高的伏隔核体积。这种结构异常的模式可能是疼痛和情绪失调的基础,这与从自杀想法到行动的转变有关。

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DOI:10.1007/s11033-021-06299-9
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