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Meta-Analysis of white matter diffusion tensor imaging alterations in borderline personality disorder.

边缘型人格障碍白质弥散张量成像改变的Meta分析。

  • 影响因子:2.70
  • DOI:10.1016/j.pscychresns.2020.111205
  • 作者列表:"Kelleher-Unger I","Tajchman Z","Chittano G","Vilares I
  • 发表时间:2021-01-30
Abstract

:Borderline personality disorder (BorPD) is characterized by instability and mood dysregulation, unstable relationships and distorted self-image. Identification of underlying anatomical and physiological changes is crucial to refine current treatments and develop new ones. In this perspective, previous magnetic resonance imaging studies have highlighted alterations associated with BorPD phenotype. In particular, diffusion-weighted imaging/Diffusion tensor imaging (DWI/DTI) has identified many white matter structural alterations in individuals with this diagnosis. Although in its infancy, limiting this line of investigation is a lack of direction at the field level. Hence, the present paper aims to conduct a meta-analysis of DWI/DTI findings in individuals with a diagnosis of BorPD, testing the hypothesis that there are specific white matter alterations associated with BorPD. To this end, we performed a meta-analysis of the existing literature of DWI/DTI in BorPD representing a total of 123 individuals with BorPD and 117 Controls. Our results indicated that individuals with BorPD show regions of reduced fractional anisotropy in the corpus callosum and fornix. These results survived all jack-knife reshuffles and showed no publication bias. This suggests that alterations in these structures may contribute to psychopathology. Further, the present results lend support to extant psychological and biological models of BorPD.

摘要

: 边缘型人格障碍 (BorPD) 的特征是不稳定和情绪失调,不稳定的关系和扭曲的自我形象。识别潜在的解剖和生理变化对于改进当前的治疗和开发新的治疗是至关重要的。从这个角度来看,以前的磁共振成像研究强调了与BorPD表型相关的改变。特别地,扩散加权成像/扩散张量成像 (DWI/DTI) 已经在具有这种诊断的个体中识别出许多白质结构改变。虽然处于起步阶段,但限制这一调查线是缺乏实地层面的方向。因此,本文旨在对诊断为BorPD的个体的DWI/DTI结果进行荟萃分析,检验存在与BorPD相关的特定白质改变的假设。为此,我们对BorPD中DWI/DTI的现有文献进行了荟萃分析,代表了总共123名BorPD个体和117名对照。我们的结果表明,患有BorPD的个体在胼胝体和穹窿中显示出部分各向异性降低的区域。这些结果在所有jack-knife重新洗牌中存活,并且没有显示发表偏倚。这表明这些结构的改变可能有助于精神病理学。此外,目前的结果为BorPD现存的心理和生物模型提供了支持。

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