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White Matter Integrity According to the Stage of Mental Disorder in Youth.

白质完整性根据青年时期的精神障碍阶段。

  • 影响因子:0
  • DOI:10.1016/j.pscychresns.2020.111218
  • 作者列表:"Sacks DD","Lagopoulos J","Hatton SN","Iorfino F","Carpenter JS","Crouse JJ","Naismith SL","Scott EM","Hickie IB","Hermens DF
  • 发表时间:2021-01-30
Abstract

:The present study investigated differences in white matter (WM) integrity between 96 young people with affective and/or psychotic symptoms classified at an early stage of mental disorder (i.e. 'attenuated syndrome'; stage 1b), 85 young people classified at a more advanced stage of mental disorder (i.e. 'discrete disorder'; stage 2), and 81 demographically matched healthy controls using diffusion tensor imaging. The relationship between WM integrity (indexed by fractional anisotropy; FA) across the tracts and neuropsychological functioning was also investigated. A significant reduction in FA was identified in those with more advanced disorder in the body of the corpus callosum. Clinical stage groups were associated with significant neuropsychological impairment, which was significantly greater in those with discrete disorders. Compared to those in the earlier stage of disorder, participants at the later clinical stage showed decreased FA in the body of the corpus callosum that was associated with worse performance in attentional set formation maintenance, shifting and flexibility. These results provide further support for clinical staging of mental disorder and highlight the potential for utilising neuroanatomical biomarkers to support the classification of stages of mental disorder in the future.

摘要

: 本研究调查了96名患有情感和/或精神病性症状的年轻人在精神障碍的早期阶段 (即“减毒综合征”; 阶段1b),85名年轻人被分类为精神障碍的更晚期阶段 (即“离散障碍”; 第2期),并使用扩散张量成像对81名人口统计学匹配的健康对照进行了研究。还研究了跨束的WM完整性 (由部分各向异性索引; FA) 与神经心理功能之间的关系。在胼胝体的更晚期疾病的患者中发现FA显著降低。临床分期组与显著的神经心理损伤相关,这在具有离散病症的患者中显著更大。与处于疾病早期阶段的参与者相比,处于后期临床阶段的参与者显示胼胝体体内的FA降低,这与注意力集中形成维持、移动和灵活性的较差表现相关。这些结果为精神障碍的临床分期提供了进一步的支持,并强调了利用神经解剖学生物标志物来支持未来精神障碍的分期分类的潜力。

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