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High schizotypy traits are associated with reduced hippocampal resting state functional connectivity.

高分裂型性状与海马静息状态功能连接减少相关。

  • 影响因子:0
  • DOI:10.1016/j.pscychresns.2020.111215
  • 作者列表:"P K","F S","A D","P A
  • 发表时间:2021-01-30
Abstract

:Altered hippocampal functioning is proposed to play a critical role in the development of schizophrenia-spectrum disorders. Previous resting state functional Magnetic Resonance Imaging (rs-fMRI) studies report disrupted hippocampal connectivity in patients with psychosis and in individuals with clinical high risk, yet hippocampal connectivity has not been investigated in people with high schizotypy traits. Here we used rs-fMRI to examine hippocampal connectivity in healthy people with low (LS, n = 23) and high levels (HS, n = 22) of schizotypal traits assessed using the Schizotypy Personality Questionnaire. Using a bilateral hippocampal seed region, we examined resting state functional connectivity (RSFC) between hippocampus and striatal, thalamic and prefrontal cortex regions of interest. Compared to LS, HS participants showed lower RSFC between hippocampus and striatum and between hippocampus and thalamus. Whilst the group effect of reduced hippocampal RSFC in striatal and thalamic regions was driven by total schizotypy scores, positive schizotypy subfactor scores were significantly positively correlated with hippocampus-caudate/thalamus RSFC. Group differences in RSFC were not observed between hippocampus and prefrontal cortex. These results demonstrate that subclinical schizotypal traits are associated with altered hippocampal connectivity in striatal and thalamic regions and provide further support that hippocampal dysconnectivity confers risk for schizophrenia spectrum disorders.

摘要

: 海马功能改变被认为在精神分裂症谱系障碍的发展中发挥关键作用。先前的静息态功能磁共振成像 (rs-fMRI) 研究报告精神病患者和临床高风险个体的海马连接被破坏,然而海马连接尚未在具有高分裂型特征的人群中进行研究。在这里,我们使用rs-fMRI检查健康人的海马连接性,使用分裂型人格问卷评估低 (LS,n = 23) 和高 (HS,n = 22) 的分裂型特征。使用双侧海马种子区,我们检查了海马与纹状体、丘脑和前额叶皮层感兴趣区域之间的静息状态功能连接 (RSFC)。与LS相比,HS参与者在海马和纹状体之间以及海马和丘脑之间显示出较低的RSFC。虽然纹状体和丘脑区域减少的海马RSFC的组效应是由总分裂型评分驱动的,阳性分裂型亚因子评分与海马-尾状核/丘脑RSFC显著正相关。在海马和前额叶皮层之间未观察到RSFC的组差异。这些结果表明,亚临床分裂型性状与纹状体和丘脑区海马连接改变相关,并进一步支持海马连接障碍赋予精神分裂症谱系障碍的风险。

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