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Recanalization of Embolized Endovascular Intracranial Aneurysms and Changes in the Blood Viscosity: A Pilot Study.

血管内栓塞颅内动脉瘤的再通与血液粘度的变化: 一项初步研究。

  • 影响因子:2.03
  • DOI:10.12659/MSM.919059
  • 作者列表:"Morga R","Moskała M","Popiela T","Rajzer M","Wilk A","Kłosiński M","Muszyński T","Trystuła M
  • 发表时间:2020-03-31
Abstract

:BACKGROUND The purpose of our research was to evaluate the relationships between blood viscosity and recanalization of coiled intracranial aneurysms. MATERIAL AND METHODS The study included consecutives patients treated endovascularly by a team of experienced neurosurgeons and neuroradiologists due to brain aneurysm. A total of 50 patients (the average age was 57.48 years, SD=13.71) were assigned to 2 groups: group A with recanalization (4 male and 8 female patients) and group B without recanalization (10 male and 28 female patients) were examined. All patients underwent a 6-month follow-up of the whole-blood viscosity test with a Brookfield DV III+pro cone-plate viscometer using the Rheocalc program. Differences between groups were assessed using the Statistica 12 computer program (StatSoft Inc., Tulsa, OK, USA). RESULTS Studies have shown no significant difference in the age range between group A and B (P=0.31). In group A, higher viscosity values were found for whole blood [median: 4.14 dyn×sec/cm² (mPa×sec) quartile range 0.42], compared to group B [median: 3.92 dyn×sec/cm² (mPa×sec); quartile range 0.40; (P=0.04)]. This difference was significant (P=0.04). Additionally, the level of hematocrit was positively related with recanalization, the higher the hematocrit, the more frequent recanalization. A very strong and statistically significant relationship occurred between the frequency of recanalization and smoking (P<0.001). CONCLUSIONS The occurrence of higher values of whole blood viscosity which increase turbulent flow through the vessels may be a risk for recanalization of the coiled intracranial aneurysm.

摘要

背景: 我们研究的目的是评估血液粘度与卷曲颅内动脉瘤血管再通之间的关系。材料和方法该研究包括由一组经验丰富的神经外科医生和神经放射科医生因脑动脉瘤进行血管内治疗的连续患者。共 50 例患者 (平均年龄 57.48 岁,SD = 13.71) 被分配到 2 组: A 组再通 (4 例男性和 8 例女性患者) 未再通的 B 组 (男性 10 例,女性 28 例)。所有患者使用 Rheocalc 程序,用 Brookfield DV III + pro 锥板粘度计进行了 6 个月的全血粘度试验随访。使用 Statistica 12 计算机程序 (StatSoft inc.,Tulsa,OK,USA) 评估组间差异。结果研究显示 A 组和 B 组的年龄范围无显著差异 (P = 0.31)。在 A 组中,发现全血粘度值较高 [中位数: 4.14 dyn × sec/cm ² (mpa × sec) 四分位数范围 0.42],而 B 组 [中位数: 3.92 dyn × sec/cm ² (mpa × sec); 四分位数范围 0.40; (P = 0.04)]。这种差异是显著的 (P = 0.04)。红细胞压积与血管再通呈正相关,红细胞压积越高,血管再通越频繁。复通频率与吸烟之间存在非常强且具有统计学意义的关系 (P<0.001)。结论较高的全血粘度值增加血管湍流的发生可能是盘绕颅内动脉瘤血管再通的危险因素。

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影响因子:3.29
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