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MRI patterns indicate treatment success and tumor relapse following radiofrequency ablation of osteoblastoma

MRI 模式表明骨母细胞瘤射频消融后治疗成功和肿瘤复发。

  • 影响因子:3.58
  • DOI:10.1080/02656736.2020.1739763
  • 作者列表:"Laurent Kintzelé","Simone Christine Brandelik","Felix Wuennemann","Marc-André Weber","Burkhard Lehner","Hans-Ulrich Kauczor","Christoph Rehnitz
  • 发表时间:2020-04-02
Abstract

Purpose: To explore the typical magnetic resonance imaging (MRI) pattern of osteoblastoma (OB) after radiofrequency ablation (RFA) treatment and to identify signs indicating treatment success or relapse. Materials and methods: Forty-four follow-up MRI examinations of 15 patients with OB who had undergone 19 RFA procedures were analyzed retrospectively. An early follow-up group (1–4 months after RFA) and a late follow-up group (8–131 months after RFA) were established. The groups were further subdivided according to treatment success. Images were analyzed for the presence of central nidus enhancement (CNE), peripheral nidus enhancement (PNE), perifocal bone marrow edema (PBME) and fatty nidus conversion (FNC). Results: The early follow-up MRI image from every patient in the treatment success group exhibited a target-like appearance with negative CNE and positive PNE or PBME. PNE and PBME were observed in 93% and 71% of the early follow-up images, respectively. A target-like appearance was observed in 25% of the late follow-up images, and PNE and PBME were each observed in 20% of these images. FNC was not observed in the early follow-up images, but was seen in 55% of the late follow-up images. All three MRI images of the patients exhibiting clinical recurrence demonstrated strong CNE, PNE and extensive PMBE, which was in contrast to the images of the patients exhibiting treatment success. Conclusion: A target-like appearance of OB in early follow-up MRI examination indicates treatment success. PNE and PBME typically reduce over time and can lead to FNC in successfully treated patients. CNE recurrence, PNE and extensive PBME are signs of relapse.

摘要

目的: 探讨骨母细胞瘤 (OB) 射频消融 (RFA) 治疗后典型的磁共振成像 (MRI) 模式,确定治疗成功或复发的征象。材料和方法: 回顾性分析 15 例接受 19 次 RFA 手术的 OB 患者的 44 例随访 MRI 检查结果。建立早期随访组 (RFA 后 1-4 个月) 和晚期随访组 (RFA 后 8-131 个月)。根据治疗成功进一步细分各组。分析图像是否存在中央病灶增强 (CNE) 、外周病灶增强 (PNE) 、灶周骨髓水肿 (PBME) 和脂肪病灶转化 (FNC)。结果: 治疗成功组患者的早期随访 MRI 表现为靶样外观,CNE 阴性,PNE 或 PBME 阳性。PNE 和 PBME 分别在 93% 和 71% 的早期随访图像中观察到。在 25% 的后期随访图像中观察到目标样外观,在 20% 的这些图像中分别观察到 PNE 和 PBME。早期随访图像中未观察到 FNC,但在 55% 的晚期随访图像中观察到 FNC。表现为临床复发的患者的 3 个 MRI 图像均表现出较强的 CNE 、 PNE 和广泛的 PMBE,这与表现为治疗成功的患者的图像相反。结论: 早期随访 MRI 检查中 OB 的靶样表现表明治疗成功。PNE 和 PBME 通常随着时间的推移而降低,并可在成功治疗的患者中导致 FNC。CNE 复发、 PNE 和广泛 PBME 是复发的征象。

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DOI:10.1016/j.canlet.2019.12.041
作者列表:["Yang D","Liu K","Fan L","Liang W","Xu T","Jiang W","Lu H","Jiang J","Wang C","Li G","Zhang X"]

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影响因子:11.08
发表时间:2020-01-13
DOI:10.1200/JCO.19.00827
作者列表:["Kelley LM","Schlegel M","Hecker-Nolting S","Kevric M","Haller B","Rössig C","Reichardt P","Kager L","Kühne T","Gosheger G","Windhager R","Specht K","Rechl H","Tunn PU","Baumhoer D","Wirth T","Werner M","von Kalle T","Nathrath M","Burdach S","Bielack S","von Lüttichau I"]

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