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Abnormal bowel movement frequency increases the risk of rectal cancer : Evidence from cohort studies with one million people.

排便频率异常增加直肠癌风险: 来自 100万人队列研究的证据。

  • 影响因子:2.87
  • DOI:10.1042/BSR20200355
  • 作者列表:"Shen L","Li C","Li N","Shen L","Li Z
  • 发表时间:2020-03-31
Abstract

:Previous studies from case-control studies failed to draw reliable conclusions regarding the relationship between bowel movement frequency and the risk of colorectal cancer. To further examine this relationship, we collect the data from cohort studies data make a more accurate estimation. Several online data were searched from inception to February 29, 2020. Ten cohort studies involving 1,038,598 individuals were included in our study. The pooled results indicated that a bowel movement of less than once per day was not associated with the risk of colorectal cancer (relative risk (RR)=1.00, 95% confidence interval (CI): 0.87-1.16, P=0.950) compared with that of once per day. Compared with a bowel movement frequency of once per day, a bowel movement of more than once per day was also not related to elevated risk of colorectal cancer (RR=1.04, 95% CI: 0.91-1.19, P=0.570). The subgroup analyses indicated a low or high bowel movement frequency did not increase the risk of colon cancer (RR=0.91, 95% CI: 0.80-1.03, P=0.130). However, an increased frequency of bowel movements increased the risk of rectal cancer (RR=1.34, 95% CI: 1.19-1.52, P<0.001). The sensitivity analysis still supports the results. Bo significant publication bias existed. The data from cohort indicated that less bowel movement frequency was not associated with the risk of colorectal cancer. The frequency of bowel movement affects the risk of rectal cancer.

摘要

: 以前来自病例对照研究的研究未能得出关于排便频率与结直肠癌风险之间关系的可靠结论。为了进一步检验这种关系,我们从队列研究数据中收集数据,做出更准确的估计。从开始到 2020年2月29日,搜索了几个在线数据。我们的研究包括 10 项队列研究,涉及 1,038,598 例个体。汇总结果表明,每天排便少于一次与结直肠癌风险无关 (相对风险 (RR)= 1.00,95% 置信区间 (CI): 0.87-1.16,P = 0.950) 与每天 1 次相比。与每天排便一次的频率相比,每天排便一次以上也与结直肠癌风险升高无关 (RR = 1.04,95% CI: 0.91-1.19,P = 0.570)。亚组分析表明,低或高排便频率不增加结肠癌的风险 (RR = 0.91,95% CI: 0.80-1.03,P = 0.130)。然而,排便频率增加增加直肠癌的风险 (RR = 1.34,95% CI: 1.19-1.52,P<0.001)。灵敏度分析仍然支持结果。Bo 存在显著的发表偏倚。来自队列的数据表明,较少的排便频率与结直肠癌的风险无关。排便的频率影响直肠癌的风险。

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DOI:10.1016/j.bbrc.2020.01.048
作者列表:["Li Y","Wang Z","Jin J","Zhu SX","He GQ","Li SH","Wang J","Cai Y"]

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影响因子:2.46
发表时间:2020-01-01
DOI:10.1097/COC.0000000000000609
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