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Prognostic impact of acellular mucin pools towards the patients with locally advanced rectal cancer achieving pathological complete response after preoperative chemoradiotherapy.

脱细胞粘蛋白池对术前放化疗后达到病理完全缓解的局部晚期直肠癌患者的预后影响。

  • 影响因子:3.85
  • DOI:10.1177/1756284820911259
  • 作者列表:"Zhang L","Guan H","Luo Q","Yuan L","Mao Y","Wu X","Pan Z","Lin J","Peng J
  • 发表时间:2020-03-25
Abstract

Background:To date, the prognostic significance of acellular mucin pools in tumors from patients with locally advanced rectal cancer (LARC) undergoing preoperative chemoradiotherapy (CRT) and subsequently obtaining pathological complete response (pCR) has not been well determined. Our current study aimed to explore the prognostic impact on these patients of acellular mucin pools. Methods:We collected clinical data from 117 consecutive LARC patients who achieved pCR after preoperative CRT and then underwent radical resection. Two groups of patients were generated, according to the presence or absence of acellular mucin pools. The 5-year disease-free survival (DFS) and overall survival (OS) rates were compared between the two groups of patients. Results:A total of 27 (23.1%) patients presented with acellular mucin pools. At a median follow-up period of 64 months, patients with acellular mucin pool showed a 5-year DFS rate (96.3% versus 83.7%, p = 0.110) and 5-year OS rate (100% versus 87.5%, p = 0.054) statistically similar to those of patients without acellular mucin pools. In univariable and multivariable Cox regression analyses, the presence of acellular mucin pools was not determined as an independent risk factor for DFS [hazard ratio (HR): 0.222; 95% confidence interval (CI): 0.029-1.864; p = 0.145] or OS (HR: 0.033; 95% CI: 0.000-9.620; p = 0.238). Conclusions:Acellular mucin pools had no significant prognostic impact on LARC patients showing pCR after preoperative CRT.

摘要

背景: 迄今为止,在接受术前放化疗 (CRT) 并随后获得病理完全缓解 (pCR) 的局部晚期直肠癌 (LARC) 患者肿瘤中脱细胞黏蛋白池的预后意义还没有很好地确定。我们目前的研究旨在探讨脱细胞黏蛋白池对这些患者的预后影响。 方法: 我们收集了 117 例连续 LARC 患者的临床资料,这些患者在术前 CRT 后达到 pCR,然后接受根治性切除术。两组患者均根据有无脱细胞黏蛋白池生成。比较两组患者的 5 年无病生存率 (DFS) 和总生存率 (OS)。 结果: 共有 27 例 (23.1%) 患者出现脱细胞黏蛋白池。中位随访期 64 个月时,脱细胞黏蛋白池患者的 5 年 DFS 率为 96.3% vs 83.7%,p = 0.110 和 5 年 OS 率 (100% vs 87.5%,p = 0.054) 在统计学上与无脱细胞黏蛋白池的患者相似。在单变量和多变量 Cox 回归分析中,无细胞粘蛋白池的存在未确定为 DFS 的独立危险因素 [风险比 (HR): 0.222; 95% 置信区间 (CI): 0.029-1.864; P = 0.145] 或 OS (HR: 0.033; 95% CI: 0.000-9.620; P = 0.238)。 结论: 脱细胞黏蛋白池对术前 CRT 后显示 pCR 的 LARC 患者无显著预后影响。

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DOI:10.1016/j.bbrc.2020.01.048
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影响因子:2.46
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DOI:10.1097/COC.0000000000000609
作者列表:["Appelt AL","Andersen RF","Lindebjerg J","Jakobsen A"]

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