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Macrophages represent the major pool of IL-7Rα expressing cells in patients with myocarditis.

巨噬细胞代表心肌炎患者 il-7r α 表达细胞的主要池。

  • 影响因子:3.45
  • DOI:10.1016/j.cyto.2020.155053
  • 作者列表:"Kubin N","Richter M","Sen-Hild B","Akintürk H","Schönburg M","Kubin T","Cetinkaya A
  • 发表时间:2020-03-20
Abstract

:Myocarditis is characterized by infiltration and activation of cytokine as well as chemokine receptors frequently producing heart failure. Causes are often infections triggering inflammatory and immune responses but these initial lines of defense might be finally disastrous. To identify mediators we screened various receptors by confocal microscopy and identified cardiac interleukin-7 (IL-7) receptor-α (IL-7Rα) expressing cells in patients with myocarditis. IL-7Rα+ cells were analyzed by markers for leukocytes (CD45), B cells (CD19), T cells (CD3, CD4, CD8) and macrophages (CD68, CD163, CD206). Immune cells were hardly detected in controls. In patients with myocarditis main inflammatory populations consisted of macrophages and T cells. B cells were hardly present. 90% of CD68+ macrophages but less than 20% of CD3+ T cells were IL-7Rα+. This was surprising since T and B lymphocytes are generally regarded as the major IL-7Rα+ cells. Since IL-7 acts as a chemokine, the expression of its receptor might orchestrate cardiac macrophage infiltration. In contrast, consumption of IL-7 by IL-7Rα+ cardiac macrophages might potentially prevent a certain overshooting immune reaction and sepsis by reducing proliferation and survival of lymphocytes. Our data suggest a participation of IL-7Rα+ macrophages in the development of myocarditis and heart failure.

摘要

: 心肌炎的特征是细胞因子以及趋化因子受体的浸润和激活,经常产生心力衰竭。原因通常是感染引发炎症和免疫反应,但这些初始防线可能最终是灾难性的。为了确定介质,我们通过共聚焦显微镜筛选了各种受体,并确定了心肌炎患者表达心肌 interleukin-7 (IL-7) 受体-α (il-7r α) 的细胞。通过白细胞 (CD45) 、 b细胞 (CD19) 、 T 细胞 (CD3 、 CD4 、 CD8) 和巨噬细胞 (CD68 、 CD163 、 CD206) 的标志物分析 il-7r α + 细胞。在对照组中几乎没有检测到免疫细胞。在心肌炎患者中,主要的炎症群体包括巨噬细胞和 T 细胞。B细胞几乎不存在。90% 的 CD68 + 巨噬细胞但不到 20% 的 CD3 + T 细胞为 il-7r α +。这是令人惊讶的,因为 T 和 B 淋巴细胞通常被认为是主要的 il-7r α + 细胞。由于 IL-7 作为趋化因子,其受体的表达可能协调心脏巨噬细胞浸润。相比之下,il-7r α + 心脏巨噬细胞消耗 IL-7 可能通过减少淋巴细胞的增殖和存活来潜在地防止某种过度免疫反应和败血症。我们的数据表明 il-7r α + 巨噬细胞参与心肌炎和心力衰竭的发展。

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DOI:10.1186/s12872-019-01311-4
作者列表:["Nattawut Wongpraparut","Sarawut Siwamogsatham","Tomorn Thongsri","Pornchai Ngamjanyaporn","Arintaya Phrommintikul","Kompoj Jirajarus","Tarinee Tangcharoen","Kid Bhumimuang","Pinij Kaewsuwanna","Rungroj Krittayaphong","Rungtiwa Pongakasira","Harvey D. White"]

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影响因子:4.69
发表时间:2020-01-07
DOI:10.1186/s12968-019-0590-z
作者列表:["Yao-Dan Liang","Yuan-Wei Xu","Wei-Hao Li","Ke Wan","Jia-Yu Sun","Jia-Yi Lin","Qing Zhang","Xiao-Yue Zhou","Yu-Cheng Chen"]

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影响因子:4.69
发表时间:2020-01-05
DOI:10.1186/s12968-019-0589-5
作者列表:["Yingxia Yang","Gang Yin","Yong Jiang","Lei Song","Shihua Zhao","Minjie Lu"]

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