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Association between venous thromboembolism and acute pancreatitis: An analysis from the nationwide inpatient sample.

静脉血栓栓塞症与急性胰腺炎的相关性: 来自全国住院患者样本的分析。

  • 影响因子:1.39
  • DOI:10.1111/crj.13134
  • 作者列表:"Chung WS","Lin CL
  • 发表时间:2020-04-01
Abstract

BACKGROUND AND AIMS:Acute inflammation of the pancreas may trigger a systemic inflammatory response and initiate coagulation. Few studies have been conducted on the association between venous thromboembolism (VTE) and acute pancreatitis (AP). We investigated the incidence and risk of VTE in patients with AP. METHODS:We conducted a retrospective cohort analysis for the nationwide AP cohort. We identified 91 786 patients with AP and 183 557 controls who were frequency-matched according to sex, age (5-y interval), and index year from the National Health Insurance Research Database between 2000 and 2008. The patients and controls were followed until diagnosis of deep vein thrombosis (DVT) or pulmonary embolism (PE), death or the end of 2011. RESULTS:The nationwide cohort study showed that patients with AP exhibited a higher incidence of VTE (13.1 vs 5.65 per 10 000 person-y) than did the controls. After covariates were controlled for, the patients with AP had a 1.88-fold higher risk of VTE than did the controls (adjusted hazard ratios [aHR] = 1.88; 95% confidence intervals [CI] = 1.68-2.10). The incidence rates of DVT and PE were higher in the patients with AP than in the controls, irrespective of sex, age or comorbidity. The patients with AP exhibited a 1.86-fold higher aHR of DVT (95% CI = 1.63-2.12) and a 1.92-fold higher aHR of PE (95% CI = 1.59-2.31) than did the controls. CONCLUSION:Patients with AP exhibited a significantly higher risk of VTE than did the controls.

摘要

背景和目的: 胰腺的急性炎症可能引发全身炎症反应并启动凝血。关于静脉血栓栓塞症 (VTE) 和急性胰腺炎 (AP) 之间的关系的研究很少。我们调查了 AP 患者 VTE 的发生率和风险。 方法: 我们对全国 AP 队列进行了回顾性队列分析。我们从 786 和 2000年的国家健康保险研究数据库中确定了 91 183 例 AP 患者和 557 2008 例对照,根据性别、年龄 (5-y 间期) 和指数年份进行频率匹配。随访患者和对照直至确诊为深静脉血栓形成 (DVT) 或肺栓塞 (PE) 、死亡或 2011年底。 结果: 全国队列研究显示,AP 患者的 VTE 发生率 (13.1 vs 5.65/10 000 人-y) 高于对照组。控制协变量后,AP 患者发生 VTE 的风险是对照组的 1.88 倍 (校正风险比 [aHR] = 1.88; 95% 置信区间 [CI] = 1.68-2.10)。AP 患者 DVT 和 PE 的发生率高于对照组,与性别、年龄或合并症无关。AP 患者表现为 DVT 的 aHR 高 1.86 倍 (95% CI = 1.63-2.12),PE 的 aHR 高 1.92 倍 (95% CI = 1.59-2.31) 比对照组还多。 结论: AP 患者发生 VTE 的风险显著高于对照组。

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