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Influence of the Preoperative C-Reactive Protein-to-Albumin Ratio on Survival and Recurrence in Patients With Esophageal Cancer.

术前 C 反应蛋白与白蛋白比值对食管癌患者生存和复发的影响。

  • 影响因子:1.90
  • DOI:10.21873/anticanres.14205
  • 作者列表:"Tamagawa H","Aoyama T","Tamagawa A","Komori K","Maezawa Y","Kano K","Murakawa M","Atsumi Y","Hara K","Kazama K","Numata M","Oshima T","Yukawa N","Masuda M","Rino Y
  • 发表时间:2020-04-01
Abstract

BACKGROUND:Several immune-inflammatory markers are associated with cancer progression. The purpose of the present study was to clarify the influence of the preoperative C-reactive protein-to-albumin ratio (CRP/ALB ratio) on survival of patients with esophageal cancer and recurrence after curative resection. PATIENTS AND METHODS:The preoperative CRP/ALB ratio was evaluated in 122 patients who underwent radical resection for esophageal cancer from 2005 to 2018. The correlations between the CRP/ALB ratio and cancer-specific overall (OS), recurrence-free (RFS) survival and the clinicopathological status were analyzed. RESULTS:The optimal cut-off value of the CRP/ALB ratio determined using receiver operating characteristic curve analysis was 0.04. Patients were divided into two groups based on this cut-off value: the low CRP/ALB group (n=59) and the high CRP/ALB group (n=50). The OS rate at 5 years after surgery was significantly lower in the group with high CRP/ALB at 40.5% whilst it was 63.5% in the low CRP/ALB group (p=0.005). The corresponding RFS rates at 5 years after surgery were 32.5% and 48.3%, respectively, which was a statistically significant difference (p=0.007). A multivariate analysis showed that a high CRP/ALB ratio was a significant independent risk factor for poorer cancer-specific OS and RFS. CONCLUSION:The preoperative CRP/ALB ratio was a strong prognostic marker for patients with esophageal cancer. The surgical strategy, including procedure and perioperative care should be carefully planned for patients with a high CRP/ALB ratio.

摘要

背景: 几种免疫炎症标志物与癌症进展相关。本研究的目的是阐明术前 C 反应蛋白与白蛋白比值 (CRP/ALB 比值) 的影响。食管癌患者的生存和根治性切除术后复发。 患者和方法: 对 2005年至 2018年行食管癌根治术的 122 例患者进行术前 CRP/ALB 比值评估。分析 CRP/ALB 比值与肿瘤特异性总体 (OS) 、无复发生存率 (RFS) 和临床病理状态的相关性。 结果: 采用受试者工作特征曲线分析确定的 CRP/ALB 比值的最佳临界值为 0.04。根据临界值将患者分为低 CRP/ALB 组 (n = 59) 和高 CRP/ALB 组 (n = 50)。高 CRP/ALB 组术后 5 年的 OS 率显著低于 40.5%,而低 CRP/ALB 组为 63.5% (p = 0.005)。术后 5 年相应 RFS 率分别为 32.5% 和 48.3%,差异有统计学意义 (p = 0.007)。多变量分析显示,高 CRP/ALB 比值是较差癌症特异性 OS 和 RFS 的显著独立危险因素。 结论: 术前 CRP/ALB 比值是食管癌患者较强的预后指标。对于 CRP/ALB 比值较高的患者,应仔细规划手术策略,包括手术和围手术期护理。

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影响因子:1.24
发表时间:2020-01-01
DOI:10.3892/etm.2019.8190
作者列表:["Shang L","Pei QS","Xu D","Liu JY","Liu J"]

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影响因子:2.64
发表时间:2020-01-01
DOI:10.1007/s11605-019-04456-x
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