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Serum amyloid A is a better predictive biomarker of mucosal healing than C-reactive protein in ulcerative colitis in clinical remission

血清淀粉样蛋白 A 是临床缓解期溃疡性结肠炎黏膜愈合较 C 反应蛋白更好的预测生物标志物

  • 影响因子:2.76
  • DOI:10.1186/s12876-020-01229-8
  • 作者列表:"Masaki Wakai","Ryohei Hayashi","Shinji Tanaka","Toshikatsu Naito","Junko Kumada","Motonobu Nomura","Hidehiko Takigawa","Shiro Oka","Yoshitaka Ueno","Masanori Ito","Kazuaki Chayama
  • 发表时间:2020-04-03
Abstract

Abstract Background Many studies have revealed that mucosal healing improves the long-term prognosis of ulcerative colitis. Frequent colonoscopy is difficult because of its invasiveness and cost. Therefore, in diagnosing and treating ulcerative colitis, noninvasive, low-cost methods for predicting mucosal healing using useful biomarkers are required in the clinical setting. This study aimed to evaluate whether serum amyloid A is a better serum biomarker than C-reactive protein in predicting mucosal healing in ulcerative colitis patients in clinical remission. Methods Ulcerative colitis patients whose C-reactive protein and serum amyloid A were measured within 1 month before and after colonoscopy were included in this retrospective study, and the relationship between the C-reactive protein and serum amyloid A values and the mucosal condition was analyzed. Mucosal condition was assessed using the Mayo Endoscopic Score, with score 0 or 1 indicating mucosal healing. Results A total of 199 colonoscopic examinations were conducted in 108 ulcerative colitis patients who underwent C-reactive protein and serum amyloid A blood tests. In clinical remission patients, serum amyloid A showed a strong correlation with mucosal inflammation compared to C-reactive protein and had excellent sensitivity and specificity rates with significant statistical significance. Conclusions Serum amyloid A is a more useful marker compared to C-reactive protein in predicting mucosal inflammation in ulcerative colitis patients in clinical remission.

摘要

文摘背景许多研究揭示黏膜愈合改善溃疡性结肠炎的远期预后。频繁的结肠镜检查是困难的,因为它的侵袭性和成本。因此,在诊断和治疗溃疡性结肠炎时,临床上需要使用有用的生物标志物预测粘膜愈合的无创、低成本的方法。本研究旨在评估血清淀粉样蛋白 A 在预测临床缓解期溃疡性结肠炎患者黏膜愈合方面是否比 C 反应蛋白更好的血清生物标志物。方法对结肠镜检查前后 1 个月内测定 C 反应蛋白和血清淀粉样蛋白 A 的溃疡性结肠炎患者进行回顾性研究,并分析 C 反应蛋白和血清淀粉样蛋白 A 值与黏膜状况的关系。使用 Mayo 内镜评分评估黏膜状况,评分 0 或 1 表示黏膜愈合。结果 199 例溃疡性结肠炎患者共行 108 次结肠镜检查,均行 C 反应蛋白和血清淀粉样蛋白 A 血检测。在临床缓解患者中,与 C 反应蛋白相比,血清淀粉样蛋白 A 与黏膜炎症表现出很强的相关性,具有极好的敏感性和特异性,具有显著的统计学意义。结论与 C 反应蛋白相比,血清淀粉样蛋白 A 是预测临床缓解期溃疡性结肠炎患者黏膜炎症的更有用的标志物。

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影响因子:3.72
发表时间:2020-01-21
DOI:10.1093/ibd/izz331
作者列表:["Ronchetti S","Gentili M","Ricci E","Migliorati G","Riccardi C"]

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关键词: GILZ IBD 自身免疫 炎症
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