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Protective effect of rutin against bleomycin induced lung fibrosis: Involvement of TGF-β1/α-SMA/Col I and III pathway.

芦丁对博莱霉素诱导的肺纤维化的保护作用: tgf-β 1/α-SMA/Col I 和 III 通路的参与。

  • 影响因子:3.52
  • DOI:10.1002/biof.1629
  • 作者列表:"Bai L","Li A","Gong C","Ning X","Wang Z
  • 发表时间:2020-03-31
Abstract

:Lung fibrosis is a progressive fatal lung disorder with significantly high mortality rates. Bleomycin (BLM) is one of the most commonly used chemotherapeutic agents for the treatment of several carcinomas. The most severe adverse effect of BLM is lung toxicity; therefore, BLM has been repeatedly reported to be considered amongst the most widely used agents for the induction of experimental lung fibrosis. In the current study, rutin has been investigated for its ability to ameliorate BLM-induced pulmonary fibrosis. BLM was instilled intratracheally and rutin was administered orally (50 and 100 mg/kg) for 3 weeks. Rutin significantly decreased lung/body weight index, bronchoalveolar lavage fluid lactate dehydrogenase activity, total cell count, macrophages, and lymphocyte counts. Rutin significantly decreased lung malondialdehyde content, increased lung glutathione content, superoxide dismutase activity, serum total antioxidant capacity, and decreased lung nitric oxide content. Moreover, rutin reduced expressions of transforming growth factor beta 1 and other fibrosis-related biomarkers (Col I, Col III, and α-SMA). In addition, rutin significantly ameliorated histological changes and prevented collagen deposition with the paralleled decrease in lung hydroxyproline content. In conclusion, rutin can be proposed to be a potential therapeutic agent for the management of lung fibrosis.

摘要

: 肺纤维化是一种进行性致死性肺疾病,死亡率显著增高。博莱霉素 (BLM) 是治疗多种癌症最常用的化疗药物之一。BLM 最严重的不良反应是肺毒性; 因此,BLM 被反复报道为诱导实验性肺纤维化最广泛使用的药物之一。在目前的研究中,芦丁已经研究了其改善 BLM 诱导的肺纤维化的能力。气管内滴注 BLM,口服芦丁 (50 和 100 mg/kg) 3 周。芦丁显著降低肺/体重指数、支气管肺泡灌洗液乳酸脱氢酶活性、总细胞计数、巨噬细胞和淋巴细胞计数。芦丁显著降低肺丙二醛含量,增加肺谷胱甘肽含量、超氧化物歧化酶活性、血清总抗氧化能力,降低肺一氧化氮含量。此外,芦丁降低转化生长因子 β 1 和其他纤维化相关生物标志物 (Col I 、 Col III 和 α-SMA) 的表达。此外,芦丁可明显改善肺组织病理改变,防止胶原沉积,同时降低肺羟脯氨酸含量。总之,芦丁可被认为是一种潜在的治疗肺纤维化的药物。

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DOI:10.1093/rheumatology/kez673
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翻译标题与摘要 下载文献
影响因子:4.40
发表时间:2020-01-01
DOI:10.1007/s00262-019-02431-8
作者列表:["Shibaki, Ryota","Murakami, Shuji","Matsumoto, Yuji","Yoshida, Tatsuya","Goto, Yasushi","Kanda, Shintaro","Horinouchi, Hidehito","Fujiwara, Yutaka","Yamamoto, Nobuyuki","Kusumoto, Masahiko","Yamamoto, Noboru","Ohe, Yuichiro"]

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翻译标题与摘要 下载文献
影响因子:4.04
发表时间:2020-01-25
来源期刊:New biotechnology
DOI:10.1016/j.nbt.2019.08.006
作者列表:["Sousa SA","Soares-Castro P","Seixas AMM","Feliciano JR","Balugas B","Barreto C","Pereira L","Santos PM","Leitão JH"]

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