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Dissecting the Dual Role of the Glial Scar and Scar-Forming Astrocytes in Spinal Cord Injury

胶质瘢痕和瘢痕形成星形胶质细胞在脊髓损伤中的双重作用

  • 影响因子:4.22
  • DOI:10.3389/fncel.2020.00078
  • 作者列表:"Tuo Yang","Tuo Yang","YuJuan Dai","Gang Chen","Gang Chen","ShuSen Cui
  • 发表时间:2020-04-03
Abstract

Recovery from spinal cord injury (SCI) remains an unsolved problem. As a major component of the SCI lesion, the glial scar is primarily composed of scar-forming astrocytes and plays a crucial role in spinal cord regeneration. In recent years, it has become increasingly accepted that the glial scar plays a dual role in SCI recovery. However, the underlying mechanisms of this dual role are complex and need further clarification. This dual role also makes it difficult to manipulate the glial scar for therapeutic purposes. Here, we briefly discuss glial scar formation and some representative components associated with scar-forming astrocytes. Then, we analyze the dual role of the glial scar in a dynamic perspective with special attention to scar-forming astrocytes to explore the underlying mechanisms of this dual role. Finally, taking the dual role of the glial scar into account, we provide several pieces of advice on novel therapeutic strategies targeting the glial scar and scar-forming astrocytes.

摘要

脊髓损伤 (SCI) 的恢复仍然是一个尚未解决的问题。胶质瘢痕作为脊髓损伤的主要组成部分,主要由瘢痕形成的星形胶质细胞组成,在脊髓再生中起着至关重要的作用。近年来,胶质瘢痕在 SCI 恢复中起着双重作用的观点越来越被人们所接受。然而,这种双重作用的潜在机制很复杂,需要进一步澄清。这种双重作用也使得难以操纵用于治疗目的的胶质瘢痕。在此,我们简要讨论胶质瘢痕形成和一些与瘢痕形成星形胶质细胞相关的代表性成分。然后,我们从动态的角度分析了胶质瘢痕的双重作用,特别关注瘢痕形成的星形胶质细胞,以探讨这种双重作用的潜在机制。最后,考虑到胶质瘢痕的双重作用,我们提供了几条针对胶质瘢痕和瘢痕形成星形胶质细胞的新型治疗策略的建议。

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影响因子:3.21
发表时间:2020-01-31
来源期刊:Journal of neurology
DOI:10.1007/s00415-020-09716-4
作者列表:["Bukhari W","Clarke L","O'Gorman C","Khalilidehkordi E","Arnett S","Prain KM","Woodhall M","Silvestrini R","Bundell CS","Ramanathan S","Abernethy D","Bhuta S","Blum S","Boggild M","Boundy K","Brew BJ","Brownlee W","Butzkueven H","Carroll WM","Chen C","Coulthard A","Dale RC","Das C","Dear K","Fabis-Pedrini MJ","Fulcher D","Gillis D","Hawke S","Heard R","Henderson APD","Heshmat S","Hodgkinson S","Jimenez-Sanchez S","Kilpatrick TJ","King J","Kneebone C","Kornberg AJ","Lechner-Scott J","Lin MW","Lynch C","Macdonnell RAL","Mason DF","McCombe PA","Pereira J","Pollard JD","Reddel SW","Shaw C","Spies J","Stankovich J","Sutton I","Vucic S","Walsh M","Wong RC","Yiu EM","Barnett MH","Kermode AG","Marriott MP","Parratt J","Slee M","Taylor BV","Willoughby E","Wilson RJ","Brilot F","Vincent A","Waters P","Broadley SA"]

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影响因子:4.32
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