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Prevalence of non Helicobacter pylori gastric Helicobacters in Iranian dyspeptic patients.

伊朗消化不良患者中非幽门螺杆菌胃幽门螺杆菌的患病率。

  • 影响因子:2.76
  • DOI:10.1186/s12876-020-01331-x
  • 作者列表:"Shafaie S","Kaboosi H","Peyravii Ghadikolaii F
  • 发表时间:2020-06-16
Abstract

BACKGROUND:Non Helicobacter pylori gastric Helicobacters (NHPGHs) are associated with a range of upper gastrointestinal symptoms, histologic and endoscopic findings. For the first time in Iran, we performed a cross-sectional study in order to determine the prevalence of five species of NHPGHs in patients presenting with dyspepsia. METHODS:The participants were divided into H. pylori-infected and NHPGH-infected groups, based on the rapid urease test, histological analysis of biopsies, and PCR assay of ureA, ureB, and ureAB genes. The study included 428 gastric biopsies form dyspeptic patients, who did not receive any treatment for H. pylori. The samples were collected and sent to the laboratory within two years. H. pylori was identified in 368 samples, which were excluded from the study. Finally, a total of 60 non-H. pylori samples were studied for NHPGH species. RESULTS:The overall frequency of NHPGH species was 10 for H. suis (three duodenal ulcer, three gastritis, and four gastric ulcer samples), 10 for H. felis (one gastritis, three duodenal ulcer, and six gastric ulcer samples), 20 for H. salomonis (four duodenal ulcer, five gastritis, and 11 gastric ulcer samples), 13 for H. heilmannii (three gastritis, five duodenal ulcer, and five gastric ulcer samples), and 7 for H. bizzozeronii (zero gastric ulcer, two duodenal ulcer, and five gastritis samples). CONCLUSIONS:Given our evidence about the possibility of involvement of NHPGHs in patients suffering from gastritis and nonexistence of mixed H. pylori infection, bacteriological testing of subjects negative for H. pylori becomes clinically relevant and important. Our findings suggest H. salomonis has the highest rate among the NHPGH species in Iranian dyspeptic patients.

摘要

背景:非螺杆菌幽门螺杆菌(NHPGHs)与上消化道症状、组织学和内镜检查结果有关。在伊朗,我们首次进行了一项横断面研究,以确定5种NHPGHs在消化不良患者中的患病率。 方法:参与者根据尿素酶快速检测、活检组织学分析及尿素、尿素酶b、尿素酶b基因的PCR检测结果,分为hp感染组和NHPGH感染组。这项研究包括428名消化不良患者的胃活检,他们没有接受任何幽门螺杆菌治疗。样品在两年内收集并送到实验室。H、 在368个样本中发现了幽门螺杆菌,这些样本被排除在研究之外。最后,对60个非幽门螺杆菌样本进行了NHPGH种类的研究。 结果:总体猪瘟(三个十二指肠溃疡、三个胃炎和四个胃溃疡样本)的NHPGH种类频率为10,猫瘟(一个胃炎、三个十二指肠溃疡和六个胃溃疡样本)的NHPGH种类频率为10,所罗门(四个十二指肠溃疡、五个胃炎和十一个胃溃疡样本)的NHPGH种类频率为20,海尔曼氏杆菌13例(3例胃炎、5例十二指肠溃疡和5例胃溃疡样本),比佐氏杆菌7例(0例胃溃疡、2例十二指肠溃疡和5例胃炎样本)。 结论:鉴于有证据表明,在胃炎患者和不存在混合性幽门螺杆菌感染的情况下,对幽门螺杆菌阴性的受试者进行细菌学检查具有临床意义和重要意义。我们的发现表明,在伊朗消化不良患者的NHPGH物种中,所罗门氏杆菌的比例最高。

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