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Rabeprazole-amoxicillin dual therapy as first-line treatment for H pylori eradication in special patients: A retrospective, real-life study.

雷贝拉唑-阿莫西林双重治疗作为特殊患者 H.pylori 根除的一线治疗: 一项回顾性、现实生活的研究。

  • 影响因子:3.27
  • DOI:10.1111/hel.12717
  • 作者列表:"Gao W","Ye H","Deng X","Wang C","Xu Y","Li Y","Zhang X","Cheng H
  • 发表时间:2020-06-16
Abstract

BACKGROUND:The currently recommended quadruple regimens for Helicobacter pylori infection might not be appropriate for every patient, especially in elderly patients or those with multiple comorbidities. OBJECTIVE:To evaluate the efficacy and safety of rabeprazole-amoxicillin dual therapy in H pylori-positive elderly patients or those with multiple comorbidities. METHODS:From November 2013 to May 2017, the clinical data of H pylori-positive patients ≥60 years old or with multiple comorbidities were collected and reviewed. All patients were given rabeprazole 10 mg three times a day and amoxicillin 1000 mg thrice a day (RA dual therapy) for 14 days as first-line treatment. H pylori eradication was evaluated by 13 C-urea breath test 6 weeks after treatment. Adverse effects were recorded. RESULTS:A total of 198 patients were enrolled, including 116 elderly patients and 82 patients with multiple comorbidities. Successful eradication was achieved in 90.9% (180/198, 95% CI: 86.1%-94.2%) patients. Adverse effects, which were mainly mild (referring to skin rash, abdominal pain, and diarrhea), occurred in 22 patients (22/198, 11.1%) and resolved spontaneously. CONCLUSION:Dual therapy composed of rabeprazole and amoxicillin as a first-line treatment appears to be effective and safe for H pylori infection in elderly patients or those with multiple comorbidities. Additional studies are needed to optimize the regimen.

摘要

背景: 目前推荐的四联方案治疗幽门螺杆菌感染可能并不适合每一位患者,尤其是老年患者或有多种合并症的患者。 目的: 评价雷贝拉唑-阿莫西林双联治疗幽门螺杆菌 (H.pylori) 阳性的老年患者及合并多种合并症患者的疗效和安全性。 方法: 收集 2013 年 11 月至 2017 年 5 月间 ≥ 60 岁或合并多种合并症的 H.pylori 阳性患者的临床资料并进行回顾。所有患者均给予雷贝拉唑 10 mg,每日 3 次,阿莫西林 1000 mg,每日 3 次 (RA 二联治疗),一线治疗 14 天。治疗后 6 周采用 13 C-尿素呼气试验评价 H.pylori 根除情况。记录不良反应。 结果: 共入组 198 例患者,包括 116 例老年患者和 82 例有多种合并症的患者。90.9% (180/198,95% CI: 86.1%-94.2%) 患者成功根除。22 例 (22/198,11.1%) 发生不良反应,主要为轻度 (皮疹、腹痛和腹泻),且自行缓解。 结论: 雷贝拉唑和阿莫西林组成的双重疗法作为一线治疗对老年患者或有多种合并症的幽门螺杆菌感染是有效和安全的。需要额外的研究来优化方案。

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影响因子:1.71
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