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Prognostic value of cerebral infarction coefficient in patients with massive cerebral infarction.

大面积脑梗死患者脑梗死系数的预后价值。

  • 影响因子:1.70
  • DOI:10.1016/j.clineuro.2020.106009
  • 作者列表:"Du X","Liu Q","Li Q","Yang Z","Liao J","Gong H","Wu L","Wei J","Tan Q","Du H","Zhao R","Zhao L
  • 发表时间:2020-06-09
Abstract

OBJECTIVE:We proposed the concept of the cerebral infarction coefficient, which is cerebral infarction volume/brain volume. This study aimed to evaluate the prognostic value of the cerebral infarction coefficient in patients with massive cerebral infarction (MCI). METHODS:According to the modified Rankin score, 71 patients with acute MCI were divided into good prognosis and poor prognosis groups. Clinical and imaging data of the two groups were collected and univariate analysis was carried out. If there were significant differences in the data between the two groups, binary logistic regression analysis was performed. RESULTS:The poor prognosis group had a significantly higher cerebral infarction volume, cerebral infarction coefficient, and D-dimer levels, older age, the highest body temperature, a higher rate of a history of atrial fibrillation, and a lower rate of a history of hypertension compared with the good prognosis group (all P < 0.05). Binary logistic regression analysis showed that the cerebral infarction coefficient was an independent risk factor for a poor prognosis of patients with MCI (P < 0.05, 95 % confidence interval, 2.091, 42.562), and the odds ratio was 8.506. The area under the receiver operating characteristic curve for the cerebral infarction coefficient was 0.753. When the cut-off value was 7.8 %, the sensitivity of predicting a poor prognosis of patients with MCI was 92.5 %. CONCLUSION:The cerebral infarction coefficient may have predictive value in determining the prognosis of patients with MCI.

摘要

目的: 提出脑梗死系数的概念,即脑梗死体积/脑体积。本研究旨在评估脑梗死系数对大面积脑梗死 (MCI) 患者的预后价值。 方法: 根据改良 Rankin 评分将 71 例急性 MCI 患者分为预后良好组和预后不良组。收集两组患者的临床及影像学资料,进行单因素分析。如果两组数据有显著差异,则进行二元 logistic 回归分析。 结果: 预后不良组脑梗死体积、脑梗死系数、 D-二聚体水平明显增高,年龄大、体温最高、与预后良好组相比,房颤病史发生率较高,高血压病史发生率较低 (均 P <0.05)。二分类 logistic 回归分析显示脑梗死系数是 MCI 患者预后不良的独立危险因素 (P <0.05,95% 可信区间,2.091,42.562),比值比为 8.506。受试者工作特征曲线下面积为 0.753。当临界值为 7.8% 时,预测 MCI 患者预后不良的敏感性为 92.5%。 结论: 脑梗死系数对判断 MCI 患者的预后可能有预测价值。

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影响因子:2.57
发表时间:2020-01-06
DOI:10.1007/s12031-019-01474-x
作者列表:["Cheng, Xiao","Yang, Ying-Lin","Li, Wei-Han","Liu, Man","Zhang, Shan-Shan","Wang, Yue-Hua","Du, Guan-Hua"]

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影响因子:2.75
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DOI:10.1007/s00702-019-02124-7
作者列表:["Wang, Xiaodong","Shi, Cunxian","Pan, Hongxia","Meng, Xiaowen","Ji, Fuhai"]

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