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The relative survival and cure fraction of gastric cancer estimated through flexible parametric models using data from population-based cancer registration during 2003-2012 in Linzhou, China.

中国林州市 2003-2012 年期间使用基于人群的癌症登记数据,通过灵活的参数模型估计的胃癌相对生存和治愈分数。

  • 影响因子:3.3570
  • DOI:10.1002/cam4.2831
  • 作者列表:"Chen Q","Liu SZ","Zhang SK","Cao XQ","Li BY","Quan PL","Guo LW","Dong L","Sun XB","Zhang Y","Zhang JG
  • 发表时间:2020-01-28
Abstract

PURPOSE:The proportion of cured gastric cancer patients has drawn the attention of patients, physicians, and healthcare providers after comprehensive prevention and control measures were carried out for several years. Therefore, the relative survival and cure fraction were estimated in our study. METHODS:Population-based cancer registration data were used to estimate survival and cure fraction. A total of 7585 gastric cancer cases (ICD10:C16.0 ~ C16.9) were extracted and included in the final analysis. Cases were diagnosed in 2003-2012 and followed until the end of 2017. Relative survival was calculated as the ratio between the observed survival through the life-table method. The expected survival was estimated by the Ederer II method. The cure fraction was estimated using flexible parametric cure models stratified by age and calendar period when the cases were diagnosed. RESULTS:The 5-year relative survival of cardia gastric cancer increased with the calendar period of 2003-2004, 2005-2006, 2007-2008, 2009-2010, and 2011-2012 (27.5%, 28.3%, 33.5%, 38.2%, and 46.8%, respectively). The increasing trend along with the calendar periods was also observed in cure proportion of cardia gastric cancer (24.8%, 25.2%, 31.7%, 36.0%, and 43.1%, respectively). Notable improvement of cure proportion was observed in the period of 2011-2012, compared with the initial period of 2003-2004. There was an improvement of 79.8% among all gastric cancer subjects, and it was 74.1% and 55.7% in cardia gastric and noncardia gastric cancer subjects, respectively. The median survival of "uncured" patients showed no significant improvement along with the calendar periods in all age groups. CONCLUSIONS:Notable improvement of gastric cancer relative survival and cure proportion was observed in Linzhou during 2003-2012.

摘要

目的: 经过几年的综合防治措施,胃癌治愈患者的比例已经引起了患者、医生和医护人员的关注。因此,在我们的研究中估计了相对生存率和治愈分数。 方法: 基于人群的癌症登记数据被用来估计生存和治愈分数。共提取 7585 例胃癌病例 (ICD10: C16.0 ~ C16.9),纳入最终分析。病例确诊 2003-2012,随访至 2017年底。通过寿命表法计算相对存活率为观察存活率之间的比率。通过 Ederer II 方法估计预期生存率。使用灵活的参数治愈模型估计治愈分数,按病例诊断时的年龄和日历周期分层。 结果: 贲门胃癌 5 年相对生存率随日历周期 2003-2004 、 2005-2006 、 2007-2008 、 2009-2010 、和 2011-2012 (分别为 27.5% 、 28.3% 、 33.5% 、 38.2% 和 46.8%)。随着日历周期的增加,贲门胃癌的治愈比例也呈上升趋势 (分别为 24.8% 、 25.2% 、 31.7% 、 36.0% 和 43.1%)。与初始时期 2011-2012 相比,在 2003-2004 期间观察到治愈比例的显著改善。所有胃癌受试者的改善为 79.8%,贲门胃癌和非贲门胃癌受试者的改善分别为 74.1% 和 55.7%。“未治愈” 患者的中位生存期与所有年龄组的日历周期没有显著改善。 结论: 林州市 2003 ~ 2012 年胃癌相对生存率和治愈比例明显提高。

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