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Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1.

整合蛋白基因组学方法鉴定 COPD 的蛋白标记和 sorbs1 的新剪接变异体。

  • 影响因子:4.63
  • DOI:10.1136/thoraxjnl-2019-213200
  • 作者列表:"Brandsma CA","Guryev V","Timens W","Ciconelle A","Postma DS","Bischoff R","Johansson M","Ovchinnikova ES","Malm J","Marko-Varga G","Fehniger TE","van den Berge M","Horvatovich P
  • 发表时间:2020-02-01
Abstract

:Translation of genomic alterations to protein changes in chronic obstructive pulmonary disease (COPD) is largely unexplored. Using integrated proteomic and RNA sequencing analysis of COPD and control lung tissues, we identified a protein signature in COPD characterised by extracellular matrix changes and a potential regulatory role for SUMO2. Furthermore, we identified 61 differentially expressed novel, non-reference, peptides in COPD compared with control lungs. This included two peptides encoding for a new splice variant of SORBS1, of which the transcript usage was higher in COPD compared with control lungs. These explorative findings and integrative proteogenomic approach open new avenues to further unravel the pathology of COPD.

摘要

: 慢性阻塞性肺疾病 (COPD) 基因组改变与蛋白质变化的翻译在很大程度上是未知的。使用 COPD 和对照肺组织的整合蛋白质组学和 RNA 测序分析,我们在 COPD 中鉴定了一种以细胞外基质变化和 sumo2 的潜在调控作用为特征的蛋白标记。此外,与对照肺相比,我们在 COPD 中鉴定了 61 个差异表达的新的、非参考的多肽。这包括两个编码 SORBS1 新剪接变异体的肽,其中在 COPD 中的转录本使用率高于对照肺。这些探索性发现和整合蛋白基因组学方法为进一步解开 COPD 的病理开辟了新的途径。

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相关文献
影响因子:4.63
发表时间:2020-02-01
来源期刊:Thorax
DOI:10.1136/thoraxjnl-2019-213200
作者列表:["Brandsma CA","Guryev V","Timens W","Ciconelle A","Postma DS","Bischoff R","Johansson M","Ovchinnikova ES","Malm J","Marko-Varga G","Fehniger TE","van den Berge M","Horvatovich P"]

METHODS::Translation of genomic alterations to protein changes in chronic obstructive pulmonary disease (COPD) is largely unexplored. Using integrated proteomic and RNA sequencing analysis of COPD and control lung tissues, we identified a protein signature in COPD characterised by extracellular matrix changes and a potential regulatory role for SUMO2. Furthermore, we identified 61 differentially expressed novel, non-reference, peptides in COPD compared with control lungs. This included two peptides encoding for a new splice variant of SORBS1, of which the transcript usage was higher in COPD compared with control lungs. These explorative findings and integrative proteogenomic approach open new avenues to further unravel the pathology of COPD.

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