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rs1016860 of BCL2 3'UTR associates with hsa-miR-629-5p binding potential in breast cancer and gastric cancer in isfahan population.

BCL2 3 'utr 的 rs1016860 与伊斯法罕人群乳腺癌和胃癌中的 hsa-miR-629-5p 结合潜能相关。

  • 影响因子:2.60
  • DOI:10.1016/j.gene.2020.144457
  • 作者列表:"Doulabi MSH","Ghaedi K","Ranji N","Koohpar ZK
  • 发表时间:2020-02-17
Abstract

INTRODUCTION:Breast cancer is caused by the interaction of inherited and environmental risk factors. Also, gastric cancer is the second fatal carcinoma. B-cell leukemia/lymphoma 2 gene family plays a crucial role in carcinogenesis by inhibiting the apoptosis process. MATERIALS AND METHODS:In this study, 129 patients with breast cancer and 132 controls as well as 136 patients with gastric cancer and 50 controls were enrolled. We used Real time PCR to determine the genotype of the samples. Finally, we analyzed the diagram based on high temperature melting curve diagram using the MICPCR software, followed by bioinformatics prediction of rs1016860 functions. RESULTS:rs1016860 of BCL2 gene with CC, CT, and TT genotypes were observed in this region. The association of Estrogen receptor and Progesterone receptor, cancer stage and grade of cancer in the patients with genotypes was significant in breast cancer. The association of the status of primary tumor in the patients with genotypes is significant in gastric cancer (Chi-Square p <0.05 and p = 0.000 did not follow the Hardy-Weinberg equilibrium). DISCUSSION:It was predicted that the TT genotype could be dangerous in breast cancer and gastric cancer; it is expected via bioinformatics that this SNP could lead to signaling pathways of cancer progression, by altering the binding potential of miR-629-5p to BCL2 3'UTR.

摘要

引言: 乳腺癌是由遗传和环境危险因素相互作用引起的。此外,胃癌是第二致命的癌症。B细胞白血病/淋巴瘤 2 基因家族通过抑制细胞凋亡过程在癌变过程中起着至关重要的作用。 材料和方法: 本研究纳入了 129 例乳腺癌患者和 132 例对照,以及 136 例胃癌患者和 50 例对照。我们使用 Real time PCR 确定样本的基因型。最后,我们使用 MICPCR 软件分析了基于高温熔解曲线图的图,随后对 rs1016860 功能进行了生物信息学预测。 结果: 在该区域观察到 BCL2 基因 rs1016860 位点有 CC 、 CT 和 TT 基因型。乳腺癌患者雌激素受体和孕激素受体与癌症分期和癌症分级有显著相关性。胃癌患者原发肿瘤状态与基因型的相关性显著 (卡方 p <0.05,p = 0.000 未遵循 Hardy-Weinberg 平衡)。 讨论: 预测 TT 基因型在乳腺癌和胃癌中可能是危险的; 通过生物信息学预计该 SNP 可能导致癌症进展的信号通路,通过改变 miR-629-5p 与 BCL2 3 'utr 的结合潜能。

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