- 作者列表："Wittlich M","John SM","Tiplica GS","Sălăvăstru CM","Butacu AI","Modenese A","Paolucci V","D'Hauw G","Gobba F","Sartorelli P","Macan J","Kovačić J","Grandahl K","Moldovan H
BACKGROUND:Work-related solar ultraviolet radiation (UVR) is an important factor in the pathogenesis of non-melanoma skin cancer (NMSC). The World Health Organization, through the International Agency for Research on Cancer (IARC), has classified solar UVR as a group 1 carcinogen since 2012. The main problems encountered so far in the study of occupationally induced skin cancer include the lack of accurate occupational UVR dosimetry as well as insufficient distinction between occupational and leisure UVR exposure and underreporting of NMSC. OBJECTIVES:The aim of this study was to collect long-term individual UVR measurements in outdoor workers across European countries. METHODS:A prospective study was initiated through the European Academy of Dermatology and Venereology, Healthy Skin@Work Campaign, measuring UVR exposure doses at occupational settings of masons from five European countries. Measurements were performed for several consecutive months using the GENESIS-UV measurement system. RESULTS:The results identified alarming UVR exposure data. Average daily UVR doses ranged 148.40 -680.48 J/m2 in Romania, 342.4-640.8 J/m2 in Italy, 165.5-466.2 J/m2 in Croatia, 41.8-473.8 J/m2 in Denmark, and 88.15-400.22 J/m2 in Germany. Results showed an expected latitude dependence with increasing UVR yearly dosage from the north to the south of Europe. CONCLUSIONS:This study shows that outdoor workers from EU countries included in this study are exposed to high levels of occupational solar UVR, vastly exceeding the occupational exposure limits for solar UVR exposure, considered to be 1-1.33 SED/day in the period from May to September. This finding may serve as an evidence-based recommendation to authorities on implementing occupational skin cancer prevention strategies.
背景: 工作相关的太阳紫外线辐射 (UVR) 是非黑色素瘤皮肤癌 (NMSC) 发病机制中的一个重要因素。世界卫生组织，通过国际癌症研究机构 (IARC)，已将 solar UVR 列为 1 组致癌物 2012年。目前在职业诱发皮肤癌研究中遇到的主要问题包括缺乏准确的职业 UVR 剂量测定以及职业与休闲 UVR 暴露的区分不足和 NMSC 的漏报。 目的: 本研究的目的是收集欧洲国家户外工作者的长期个人紫外线测量结果。 方法: 通过欧洲皮肤病与性病学学会，健康皮肤 @ 工作运动，测量来自五个欧洲国家泥瓦匠职业环境下的 UVR 暴露剂量，启动了一项前瞻性研究。使用 GENESIS-UV 测量系统连续几个月进行测量。 结果: 结果确定了令人震惊的 UVR 暴露数据。罗马尼亚每日平均紫外线剂量范围为 148.40-680.48 J/m2，意大利为 342.4-640.8 J/m2，克罗地亚为 165.5-466.2 J/m2, 丹麦为 41.8-473.8 J/m2，德国为 88.15-400.22 J/m2。结果显示，随着从欧洲北部到南部的 UVR 年剂量的增加，预期的纬度依赖性。 结论: 这项研究表明，来自欧盟国家的户外工作人员暴露于高水平的职业性太阳能紫外线照射，大大超过了职业暴露的太阳能紫外线照射限制, 9月期间被认为是 1-1.33 SED/天。这一发现可能作为对当局实施职业性皮肤癌预防策略的循证建议。
METHODS::In colorectal cancer (CRC), hepatic arterial infusion (HAI) chemotherapy may convert primarily unresectable CRC liver metastases (CLM) into resectability, although the risk of metastatic recurrence remains high after CLM ablation. We investigated the role of antitumour immunity invoked by first-line oxaliplatin-HAI for long-term CLM outcome. In a prospective study cohort of primarily unresectable CLM, we assessed patients' fms-related tyrosine kinase 3 ligand (FLT3LG) in serum, reflecting opportune intratumoural immune activity, at baseline and following 1-3 sequences of oxaliplatin-HAI. The end points were CLM resectability and overall survival. Patients who presented an immediate twofold increment of circulating FLT3LG during the treatment and at its completion were scored as CLM resectable (16.4% with both features), were alive at final follow-up 8-12 years later. All patients experienced FLT3LG increase during the treatment course, but those who remained unresectable or had the disease converted but presented a slow and gradual FLT3LG accretion, later died of the metastatic disease. These data provide further support to our previous findings that tumour-directed immunity invoked by oxaliplatin-containing therapy predicts excellent outcome of early advanced CRC if macroscopic tumour ablation is rendered possible by the 'classic' tumour response to the cytotoxic treatment.
METHODS::Prostate cancer is one of the primary causes of death around the world. As an important drug, flutamide has been used in the clinical diagnosis of prostate cancer. However, the over dosage and improper discharge of flutamide could affect the living organism. Thus, it necessary to develop the sensor for detection of flutamide with highly sensitivity. In this paper, we report the synthesis of lanthanum cobaltite decorated halloysite nanotube (LCO/HNT) nanocomposite prepared by a facile method and evaluated for selective reduction of flutamide. The as-prepared LCO/HNT nanocomposite shows the best catalytic performance towards detection of flutamide, when compared to other bare and modified electrodes. The good electrochemical performance of the LCO/HNT nanocomposite modified electrode is ascribed to abundant active sites, large specific surface area and their synergetic effects. Furthermore, the LCO/HNT modified electrode exhibits low detection limit (0.002 μM), wide working range (0.009-145 μM) and excellent selectivity with remarkable stability. Meaningfully, the developed electrochemical sensor was applied in real environmental samples with an acceptable recovery range.
METHODS::Several studies have indicated that cancer-associated fibroblasts (CAFs) could promote cancer progression in many malignancies. However, the mechanism by which CAFs promote the growth and metastasis of lung cancer remains poorly defined. In the present study, CAFs and normal fibroblasts (NFs) were isolated from human lung cancer and adjacent tissue. The data showed that the conditional medium (CM) of CAFs could increase the proliferation, migration and invasion of lung cancer cells. Vascular cell adhesion molecule-1 (VCAM-1) showed a higher expression in CAF-CM than NF-CM, and blocking VCAM-1 in CAF-CM attenuated the proliferation and invasion of cancer cells. Further, the results showed that VCAM-1 secreted from CAFs activated AKT and MAPK signaling via receptor α4β1 integrin (very-late antigen (VLA)-4) in lung cancer cells. Moreover, CAFs promoted VCAM-1 expression and tumor growth in vivo. Additionally, bioinformatics analysis indicated a positive correlation on the CAF marker protein alpha-smooth muscle actin (α-SMA) and VCAM-1 expression, which was associated with a poor prognosis in lung cancer patients. These findings demonstrate that the VCAM-1 secreted from CAFs enhances growth and invasion by activating the AKT and MAPK signaling of lung cancer cells.