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Construction of high quality ultrathin lanthanide oxyiodide nanosheets for enhanced CT imaging and anticancer drug delivery to efficient cancer theranostics.

构建高质量超薄镧系氧化二烯纳米片,用于增强 CT 成像和抗癌药物递送至高效癌症治疗学。

  • 影响因子:9.85
  • DOI:10.1016/j.biomaterials.2019.119670
  • 作者列表:"Xu L","Xue Y","Xia J","Qu X","Lei B","Yang T","Zhang X","Li N","Zhao H","Wang M","Luo M","Zhang C","Du Y","Yan C
  • 发表时间:2020-02-01
Abstract

:Two-dimensional (2D) ultrathin nanomaterials have shown extensive attention and potential biomedical applications in cancer theranostics. Herein, for the first time, we report the synthesis of monodisperse ultrathin lanthanum oxyiodide (LaOI) nanosheets with a thickness of merely 3 nm based on a facile wet chemistry strategy. By tuning the solvent composition and molar ratios of the precursors, we can modulate the shape and thickness of the nanosheets. Furthermore, a series of ultrathin lanthanide oxyiodides are synthesized by this method with tunable morphology. LaOI nanosheets as drug delivery platform showed ultrahigh anticancer doxorubicin (DOX) loading capacity (300 wt%) and pH-responsive release behaviour, as well as excellent cellular biocompatibility and efficiently intracellular nucleus delivery of DOX. LaOI with low dose DOX demonstrate enhanced cancer cell killing ability in vitro compared with DOX. The intravenous melanoma model shows that LaOI with low dose (1 mg mL-1) could significantly inhibit the tumor growth without side toxicity, relative to pure DOX. In addition, LaOI nanosheets also act as high resolution contrast agent for enhanced X-ray computed tomography imaging relative to the commercial iohexol. In summary, the LaOI nanosheets could serve as a competitive safe and low dose drug delivery platform for highly efficiently cancer imaging and therapy.

摘要

: 二维 (2D) 超薄纳米材料在癌症治疗中表现出广泛的关注和潜在的生物医学应用。在此,我们首次报道了基于简便的湿化学策略合成厚度仅为 3 nm 的单分散超薄镧 (LaOI) 纳米片。通过调节前体的溶剂组成和摩尔比,我们可以调节纳米片的形状和厚度。此外,通过这种方法合成了一系列具有可调形貌的超薄镧系氧化物。LaOI 纳米片作为药物递送平台显示超高抗癌阿霉素 (DOX) 负载能力 (300 wt %) 和 pH 响应释放行为, 以及优良的细胞生物相容性和 DOX 的有效胞内细胞核递送。低剂量 DOX 的 LaOI 证明与 DOX 相比,体外癌细胞杀伤能力增强。静脉注射黑色素瘤模型显示,与单纯 DOX 相比,低剂量 LaOI (1 mg mL-1) 可显著抑制肿瘤生长,且无副作用。此外,相对于商业碘海醇,LaOI 纳米片还充当了增强 x射线计算机断层扫描成像的高分辨率造影剂。总之,LaOI 纳米片可以作为一个有竞争力的安全和低剂量的药物递送平台,用于高效的癌症成像和治疗。

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影响因子:4.88
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作者列表:["Suvina V","Kokulnathan T","Wang TJ","Balakrishna RG"]

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影响因子:6.50
发表时间:2020-03-31
来源期刊:Cancer letters
DOI:10.1016/j.canlet.2019.12.039
作者列表:["Zhou Z","Zhou Q","Wu X","Xu S","Hu X","Tao X","Li B","Peng J","Li D","Shen L","Cao Y","Yang L"]

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