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Partial remission in Brazilian children and adolescents with type 1 diabetes. Association with a haplotype of class II human leukocyte antigen and synthesis of autoantibodies.

巴西 1 型糖尿病儿童和青少年的部分缓解。与 II 类人类白细胞抗原的单倍型结合并合成自身抗体。

  • 影响因子:3.27
  • DOI:10.1111/pedi.12999
  • 作者列表:"Camilo DF","Pradella F","Paulino MF","Baracat ECE","Marini S","Guerra G Jr","Pavin EJ","Parisi C","Longhini ALF","Marques S","Guariento EG","Lieber SR","Macedo CF","Silva LGE","Farias AS","Santos LMB","Volpini WMG
  • 发表时间:2020-02-20
Abstract

OBJECTIVE:Characterization of partial remission using the insulin dose-adjusted HbA1c (IDAA1c) ≤ 9 definition in a multiethnic Brazilian population of children and adolescents with type 1 diabetes (T1D), in addition with the determination of both Class II HLA genotype and autoantibodies. METHODS:We analyzed the prevalence of partial remission in 51 new-onset T1D patients with a median time follow-up of 13 months from diagnosis. For this study, anti-GAD65, anti-IA2 and HLA class II genotyping were considered. RESULTS:Partial remission occurred in 41.2% of T1D patients until 3 months after diagnosis, mainly in those aged 5-15 years. We have demonstrated a significant increase in the haplotypes of class II HLA DRB1*0301-DQB1*0201 in children and adolescents with a partial remission phase of the disease (42.9% vs 21.7% in non-remitters, P = 0.0291). This haplotype was also associated with the reduction of anti-IA2 antibodies production. Homozygote DRB1*03-DQB1*0201/DRB1*03-DQB1*0201 children had the lowest prevalence of IA-2A antibodies (P = 0.0402). However, this association does not correlate with the time of the remission phase. CONCLUSION:Although the number of patients studied was reduced, our data suggested that the association between genetics and decrease in antibody production to certain islet auto-antigen may contribute, at least in part, to the remission phase of T1D. This article is protected by copyright. All rights reserved.

摘要

目的: 在巴西多种族 1 型糖尿病 (T1D) 儿童和青少年人群中,使用胰岛素剂量调整 HbA1c (IDAA1c) ≤ 9 定义表征部分缓解, 此外,还测定了 II 类 HLA 基因型和自身抗体。 方法: 我们分析了 51 例新发 T1D 患者部分缓解的患病率,中位随访时间为 13 个月。本研究考虑 anti-GAD65 、 anti-IA2 和 HLA II 类基因分型。 结果: 41.2% 的 T1D 患者在诊断后 3 个月出现部分缓解,主要见于 5 ~ 15 岁的患者。我们已经证明,在疾病部分缓解期的儿童和青少年中,II 类 HLA DRB1 * 0301-DQB1*0201 的单倍型显著增加 (42.9% vs 21.7%,在非缓解者中, P = 0.0291)。这种单倍型也与 anti-IA2 抗体产生减少有关。纯合子 DRB1 * 03-DQB1*0201/DRB1*03-DQB1*0201 儿童 IA-2A 抗体患病率最低 (P = 0.0402)。然而,这种相关性与缓解期的时间无关。 结论: 尽管研究的患者数量减少,我们的数据表明,遗传和某些胰岛自身抗原抗体产生减少之间的关联可能有助于,至少部分, 至 T1D 缓解期。本文受版权保护。保留所有权利。

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影响因子:2.76
发表时间:2020-01-30
DOI:10.1152/japplphysiol.00631.2019
作者列表:["Bonomi AG","Ten Hoor GA","De Morree HM","Plasqui G","Sartor F"]

METHODS:BACKGROUND:Low cardiorespiratory fitness (CRF) increases risk of all-cause mortality and cardiovascular events. Periodic CRF assessment can have an important preventive function. OBJECTIVE:To develop a protocol-free method to estimate CRF in daily life based on heart rate (HR) and body acceleration measurements. METHODS:Acceleration and HR data were collected from 37 subjects (M=49%) while performing a standardized laboratory activity protocol (sitting, walking, running, cycling) and during a 5-days free-living monitoring period. CRF was determined by oxygen uptake (VO2max) during maximal exercise testing. A doubly-labeled water validated equation was used to predict total energy expenditure (TEE) from acceleration data. A fitness index was defined as the ratio between TEE and HR (TEE-pulse). Activity recognition techniques were used to process acceleration features and classify sedentary, ambulatory and other activity types. Regression equations based on TEE-pulse data from each activity type were developed to predict VO2max. RESULTS:TEE-pulse measured within each activity type of the laboratory protocol was highly correlated to VO2max (r from 0.74 to 0.91). Averaging the outcome of each activity-type specific equation based on TEE-pulse from the laboratory data led to accurate estimates of VO2max (RMSE: 300.0 mlO2/min or 10%). The difference between laboratory and free-living determined TEE-pulse was 3.7 ± 11% (r =0.85). The prediction method preserved the prediction accuracy when applied to free-living data (RMSE: 367 mlO2/min or 12%). CONCLUSIONS:Measurements of body acceleration and HR can be used to predict VO2max in daily life. Activity-specific prediction equations are needed to achieve highly accurate estimates of CRF.

翻译标题与摘要 下载文献
影响因子:3.76
发表时间:2020-01-31
DOI:10.1152/ajpgi.00386.2018
作者列表:["Farr S","Stankovic B","Hoffman S","Masoudpoor H","Baker C","Taher J","Dean A","Anakk S","Adeli K"]

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