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The enrichment of maternal environment prevents pre-term birth in a mice model.

母体环境的丰富防止了小鼠模型的早产。

  • 影响因子:3.46
  • DOI:10.1530/REP-19-0572
  • 作者列表:"Schander J","Aisemberg J","Correa FG","Wolfson ML","Juriol L","Cymeryng C","Jensen F","Franchi AM
  • 发表时间:2020-01-01
Abstract

:Maternal lifestyle affects both mother health and pregnancy outcome in humans. Several studies have demonstrated that interventions oriented towards reducing stress and anxiety have positive effects on pregnancy complications such as preeclampsia, excessive gestational weight, gestational diabetes and preterm birth. In this work, we showed that the environmental enrichment (EE), defined as a noninvasive and biological significant stimulus of the sensory pathway combined with voluntary physical activity, prevented preterm birth (PTB) rate in a 41% in an inflammatory mouse model induced by the systemic administration of bacterial lipopolysaccharide (LPS). Furthermore, we found that EE modulates maternal metabolism and produces an anti-inflammatory environment that contributes to pregnancy maintenance. In pregnant mice uterus, EE reduces the expression of TLR4 and CD14 (the LPS receptor and its coactivator protein), preventing the LPS-induced increase in PGE2 and PGF2α release and nitric oxide synthase (NOS) activity. In cervical tissue, EE inhibits cervical ripening events, such as PGE2 release, matrix metalloproteinase (MMP)-9 increased activity and neutrophil recruitment, therefore conserving cervical function. It seems that EE exposure could mimic the stress and anxiety-reducing techniques mentioned above, explaining, at least partially, the beneficial effects of having a healthy lifestyle before and during gestation. Furthermore, we propose that designing an EE protocol for humans could be a noninvasive and preventive therapy for pregnancy complications, averting pre-term birth occurrence and dreaded sequelae that are present in the offspring born to soon.

摘要

: 母亲的生活方式影响人类的母亲健康和妊娠结局。一些研究表明,以减轻压力和焦虑为导向的干预措施对妊娠并发症如子痫前期、妊娠体重过重、妊娠糖尿病和早产有积极影响。在这项工作中,我们表明,环境丰富 (EE),定义为感觉通路的一种非侵入性和生物显著性刺激结合自愿体力活动,预防早产 (PTB) 在全身给予细菌脂多糖 (LPS) 诱导的炎症小鼠模型中,rate 为 41%。此外,我们发现 EE 调节母体代谢,产生有助于妊娠维持的抗炎环境。在妊娠小鼠子宫中,EE 降低 TLR4 和 CD14 (LPS 受体及其共激活蛋白) 的表达, 防止 LPS 诱导的 PGE2 和 pgf2 α 释放和一氧化氮合酶 (NOS) 活性的增加。在宫颈组织中,EE 抑制宫颈成熟事件,如 PGE2 释放、基质金属蛋白酶 (MMP)-9 活性增加和中性粒细胞募集,因此保护宫颈功能。似乎 EE 暴露可以模仿上面提到的减轻压力和焦虑的技术,至少部分地解释了在怀孕前和怀孕期间拥有健康生活方式的有益影响。此外,我们建议为人类设计一个 EE 方案可能是妊娠并发症的非侵入性和预防性治疗, 避免出生不久的后代中存在的早产发生和可怕的后遗症。

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相关文献
影响因子:3.46
发表时间:2020-01-01
DOI:10.1530/REP-19-0572
作者列表:["Schander J","Aisemberg J","Correa FG","Wolfson ML","Juriol L","Cymeryng C","Jensen F","Franchi AM"]

METHODS::Maternal lifestyle affects both mother health and pregnancy outcome in humans. Several studies have demonstrated that interventions oriented towards reducing stress and anxiety have positive effects on pregnancy complications such as preeclampsia, excessive gestational weight, gestational diabetes and preterm birth. In this work, we showed that the environmental enrichment (EE), defined as a noninvasive and biological significant stimulus of the sensory pathway combined with voluntary physical activity, prevented preterm birth (PTB) rate in a 41% in an inflammatory mouse model induced by the systemic administration of bacterial lipopolysaccharide (LPS). Furthermore, we found that EE modulates maternal metabolism and produces an anti-inflammatory environment that contributes to pregnancy maintenance. In pregnant mice uterus, EE reduces the expression of TLR4 and CD14 (the LPS receptor and its coactivator protein), preventing the LPS-induced increase in PGE2 and PGF2α release and nitric oxide synthase (NOS) activity. In cervical tissue, EE inhibits cervical ripening events, such as PGE2 release, matrix metalloproteinase (MMP)-9 increased activity and neutrophil recruitment, therefore conserving cervical function. It seems that EE exposure could mimic the stress and anxiety-reducing techniques mentioned above, explaining, at least partially, the beneficial effects of having a healthy lifestyle before and during gestation. Furthermore, we propose that designing an EE protocol for humans could be a noninvasive and preventive therapy for pregnancy complications, averting pre-term birth occurrence and dreaded sequelae that are present in the offspring born to soon.

关键词: 暂无
翻译标题与摘要 下载文献
影响因子:2.92
发表时间:2020-01-28
DOI:10.1111/aji.13226
作者列表:["Bilibio JP","Belém Gama T","Nascimento I","José Conceição Meireles A","Aguiar A","do Nascimento FC","Lorenzzoni PL"]

METHODS:PROBLEM:We aimed to investigate the main causes of recurrent miscarriage (RM) in patients with losses after spontaneous gestation (SG) and after in vitro fertilization (IVF). METHOD OF STUDY:A prospective case-control study was conducted. The eligible patients were women who had experienced two or more consecutive abortions after less than 12 weeks gestation, two consecutive losses after SG or two consecutive losses after IVF. All patients were subjected to the following evaluations: karyotyping of the aborted material, alloimmune and autoimmune marker testing, and acquired and hereditary thrombophilia marker testing. RESULTS:In total, 58 patients were eligible: 32 patients with RM after SG and 26 patients with RM after IVF. The factors associated with RM were genetic (29%), immune (14%), thrombophilic (21%), and thrombophilic and immune (24%), and only 12% of the cases were idiopathic. Comparing the two study groups (SG and IVF), all studied factors were similar, except for a higher ANA positivity observed in the SG group (SG 30.4% versus IVF 5.3%, OR 8.6 (CI 1.1 - 21.1, P 0.048). CONCLUSIONS:Our study identified the possibly factors associated with recurrent miscarriage in 86% of the cases, and these factors appear to be similar in patients with recurrent miscarriage after spontaneous gestation and IVF. This study demonstrates that IVF with PGT-A with euploid embryo transfer could reduce abortions by up to 29%, but other factors needs to be investigated even in patients undergoing in vitro fertilization.

翻译标题与摘要 下载文献
影响因子:2.02
发表时间:2020-01-19
DOI:10.1111/1471-0528.16102
作者列表:["Belloeil V","Tessier Cazeneuve C","Leclercq A","Mercier MB","Legendre G","Corroenne R"]

METHODS:OBJECTIVES:To evaluate the impact of pre-operative Music Therapy (MT) on pain in first-trimester abortion under local anaesthesia (ALA). DESIGN:Randomised controlled trial comparing patients undergoing a first-trimester ALA with or without a pre-operative MT session. SETTING:University hospital of Angers from November 2016 to August 2017. POPULATION:Patients who underwent first-trimester abortion under ALA. METHODS:Patients allocated to MT group underwent a pre-operative 20 minutes session of MT. MAIN OUTCOME MEASURES:Pain was assessed using a visual analogue scale (VAS) just before the procedure, during the procedure, at the end of the procedure and upon returning to the ward. RESULTS:159 patients were randomised (80 in MT group, and 79 in the control group). 2 patients were excluded from the control group and 6 from the MT group. Therefore, 77 patients were analysed in the control group and 74 in the MT group. The intensity of pain were similar in both the MT group and the Control group just before the procedure (VAS: 4.0±2.9 vs. 3.6±2.5, p=0.78), during the procedure (VAS: 5.3±2.5 vs. 4.9±2.9, p=0.78), at the end of the procedure (VAS: 2.7±2.4 vs. 2.6±2.4, p=0.43) and upon returning to the ward (VAS:1.8±2.0 vs. 1.5±2.0, p=0.84). The difference in pain between entering the department and returning to the room after the procedure was similar between the MT and Control groups (0.3±2.5 vs. 0.3±2.4 VAS levels difference; p=0.92). CONCLUSION:Music therapy session before an ALA procedure resulted in no improvement in patient perception of pain during a first-trimester abortion.

关键词: 流产 焦虑 音乐 疼痛
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