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Increased Oscillatory Frequency of Sleep Spindles in Combat-Exposed Veteran Men with Post-Traumatic Stress Disorder.

创伤后应激障碍战斗暴露的退伍军人睡眠纺锤波的振荡频率增加。

  • 影响因子:4.31
  • DOI:10.1093/sleep/zsaa064
  • 作者列表:"Wang C","Laxminarayan S","Ramakrishnan S","Dovzhenok A","Cashmere JD","Germain A","Reifman J
  • 发表时间:2020-04-02
Abstract

STUDY OBJECTIVES:Sleep disturbances are core symptoms of post-traumatic stress disorder (PTSD), but reliable sleep markers of PTSD have yet to be identified. Sleep spindles are important brain waves associated with sleep protection and sleep-dependent memory consolidation. The present study tested whether sleep spindles are altered in individuals with PTSD and whether the findings are reproducible across nights and subsamples of the study. METHODS:Seventy-eight combat-exposed veteran men with (n = 31) and without (n = 47) PTSD completed two consecutive nights of high-density EEG recordings in a laboratory. We identified slow (10-13 Hz) and fast (13-16 Hz) sleep spindles during N2 and N3 sleep stages and performed topographical analyses of spindle parameters (amplitude, duration, oscillatory frequency, and density) on both nights. To assess reproducibility, we used the first 47 consecutive participants (18 with PTSD) for initial discovery and the remaining 31 participants (13 with PTSD) for replication assessment. RESULTS:In the discovery analysis, compared to non-PTSD participants, PTSD participants exhibited 1) higher slow-spindle oscillatory frequency over the antero-frontal regions on both nights and 2) higher fast-spindle oscillatory frequency over the centro-parietal regions on the second night. The first finding was preserved in the replication analysis. We found no significant group differences in the amplitude, duration, or density of slow or fast spindles. CONCLUSIONS:The elevated spindle oscillatory frequency in PTSD may indicate a deficient sensory-gating mechanism responsible for preserving sleep continuity. Our findings, if independently validated, may assist in the development of sleep-focused PTSD diagnostics and interventions.

摘要

研究目的: 睡眠障碍是创伤后应激障碍 (PTSD) 的核心症状,但 PTSD 的可靠睡眠标志物尚未确定。睡眠纺锤波是与睡眠保护和睡眠依赖性记忆巩固相关的重要脑电波。本研究测试了 PTSD 个体的睡眠纺锤波是否发生了改变,以及这些发现在研究的夜晚和子样本中是否具有可重复性。 方法: 78 例有 (n = 31) 和无 (n = 47) PTSD 的战斗暴露的退伍军人在实验室完成了连续两晚的高密度脑电图记录。我们在 N2 和 N3 睡眠阶段确定了慢 (10-13Hz) 和快 (13-16Hz) 睡眠纺锤体,并对纺锤体参数 (振幅、持续时间、振荡频率) 进行了地形学分析,和密度) 在两个晚上。为了评估可重复性,我们使用前 47 例连续参与者 (18 例 PTSD) 进行初始发现,其余 31 例参与者 (13 例 PTSD) 进行复制评估。 结果: 在 discovery 分析中,与非 PTSD 参与者相比,PTSD 参与者表现出 1) 在两个夜晚和 2 上的前额区具有更高的慢纺锤体振荡频率) 第二晚中央顶叶区域上较高的快纺锤体振荡频率。第一个发现保留在复制分析中。我们发现慢或快纺锤体的振幅、持续时间或密度无显著组间差异。 结论: PTSD 中纺锤体振荡频率升高可能表明负责保持睡眠连续性的感觉门控机制存在缺陷。我们的研究结果,如果独立验证,可能有助于开发以睡眠为重点的 PTSD 诊断和干预措施。

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影响因子:4.30
发表时间:2020-01-24
来源期刊:Experimental neurology
DOI:10.1016/j.expneurol.2020.113212
作者列表:["Bertrand SJ","Zhang Z","Patel R","O'Ferrell C","Punjabi NM","Kudchadkar SR","Kannan S"]

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影响因子:1.52
发表时间:2020-01-27
来源期刊:World neurosurgery
DOI:10.1016/j.wneu.2020.01.108
作者列表:["Middlebrooks EH","Lin C","Okromelidze L","Lu CQ","Tatum WO","Wharen RE Jr","Grewal SS"]

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