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Clinical and pathological features affecting cardiac sympathetic denervation in autopsy-confirmed dementia with Lewy bodies.

影响尸检证实的路易体痴呆心脏交感神经去神经的临床和病理特征。

  • 影响因子:3.37
  • DOI:10.1111/ene.14240
  • 作者列表:"Takahashi M","Uchihara T","Yoshida M","Wakabayashi K","Kakita A","Takahashi H","Toru S","Orimo S
  • 发表时间:2020-04-02
Abstract

BACKGROUND:To clarify the features affecting cardiac sympathetic denervation in autopsy-confirmed dementia with Lewy bodies (DLB) patients. METHODS:Fifty-four autopsy-confirmed DLB patients were enrolled. Tissue samples of the left ventricular anterior wall were immunostained with anti-tyrosine hydroxylase antibody to identify catecholaminergic nerve axons. We quantified immunostained areas as residual cardiac sympathetic nerve (CSN) axons and examined the relationship between the degree of residual CSN axons and clinical and neuropathological features. RESULTS:Virtually all patients showed small amounts of residual CSN axons (0.87%, range 0.02-9.98%), with 50 patients (92.6%) showing less than 2.0% of residual axons. The patients who showed psychological symptoms within the first year of the disease had significantly more residual CSN axons than the remaining patients did (1.50% vs. 0.40%, p < 0.01). Patients with a short disease duration and neocortical-type Lewy body pathology tended to have more preserved CSN axons, although this difference was not statistically significant. Fifty-three patients (98.1%) who had neurofibrillary tangles in the brain and strong concomitant Alzheimer's disease (AD) pathology also had statistically significantly more preserved CSN axons. The patient with the most preserved CSN axons showed different characteristics from the results, except for the first symptom. CONCLUSION:Psychological symptoms within the first year of the disease, a short disease duration, neocortical-type Lewy body pathology, and strong concomitant AD pathology may be related to mild CSN degeneration in DLB patients. Thus, DLB patients with broad LB pathology in the brain in the early stages may show mild CSN degeneration.

摘要

背景: 阐明影响路易体 (DLB) 患者尸检证实的痴呆的心脏交感神经去神经功能的特征。 方法: 54 例经尸检证实的 DLB 患者入组。用抗酪氨酸羟化酶抗体对左心室前壁组织标本进行免疫染色,以鉴定儿茶酚胺能神经轴突。我们将免疫染色区域量化为残余心脏交感神经 (CSN) 轴突,并检查残余 CSN 轴突的程度与临床和神经病理特征之间的关系。 结果: 几乎所有患者都显示少量残留的 CSN 轴突 (0.87%,范围 0.02-9.98%),50 例患者 (92.6%) 显示少于 2.0% 的残留轴突。在疾病第一年内出现心理症状的患者 CSN 轴突残留明显多于其余患者 (1.50% vs. 0.40%,p <0.01)。病程短、新皮层型路易体病理的患者倾向于保留更多的 CSN 轴突,尽管这种差异无统计学意义。53 例 (98.1%) 脑部有神经原纤维缠结和强烈伴随阿尔茨海默病 (AD) 病理的患者也有统计学显著更多的 CSN 轴突保留。CSN 轴突保存最多的患者,除首发症状外,其特征与结果不同。 结论: 疾病第一年内的心理症状、病程短、新皮层型路易体病理、伴发 AD 病理强烈可能与 DLB 患者 CSN 轻度变性有关。因此,早期脑内有广泛 LB 病理的 DLB 患者可能表现为轻度 CSN 变性。

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影响因子:3.92
发表时间:2020-01-01
DOI:10.1111/bpa.12761
作者列表:["Sebastián-Serrano Á","Simón-García A","Belmonte-Alfaro A","Pose-Utrilla J","Santos-Galindo M","Del Puerto A","García-Guerra L","Hernández IH","Schiavo G","Campanero MR","Lucas JJ","Iglesias T"]

METHODS::Huntington's disease (HD) is an inherited progressive neurodegenerative disease characterized by brain atrophy particularly in the striatum that produces motor impairment, and cognitive and psychiatric disturbances. Multiple pathogenic mechanisms have been proposed including dysfunctions in neurotrophic support and calpain-overactivation, among others. Kinase D-interacting substrate of 220 kDa (Kidins220), also known as ankyrin repeat-rich membrane spanning (ARMS), is an essential mediator of neurotrophin signaling. In adult brain, Kidins220 presents two main isoforms that differ in their carboxy-terminal length and critical protein-protein interaction domains. These variants are generated through alternative terminal exon splicing of the conventional exon 32 (Kidins220-C32) and the recently identified exon 33 (Kidins220-C33). The lack of domains encoded by exon 32 involved in key neuronal functions, including those controlling neurotrophin pathways, pointed to Kidins220-C33 as a form detrimental for neurons. However, the functional role of Kidins220-C33 in neurodegeneration or other pathologies, including HD, has not been explored. In the present work, we discover an unexpected selective downregulation of Kidins220-C33, in the striatum of HD patients, as well as in the R6/1 HD mouse model starting at early symptomatic stages. These changes are C33-specific as Kidins220-C32 variant remains unchanged. We also find the early decrease in Kidins220-C33 levels takes place in neurons, suggesting an unanticipated neuroprotective role for this isoform. Finally, using ex vivo assays and primary neurons, we demonstrate that Kidins220-C33 is downregulated by mechanisms that depend on the activation of the protease calpain. Altogether, these results strongly suggest that calpain-mediated Kidins220-C33 proteolysis modulates onset and/or progression of HD.

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