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Successful Treatment of In-Transit Metastatic Melanoma in a Renal Transplant Patient With Combination T-VEC/Imiquimod Immunotherapy.

联合 T-VEC/咪喹莫特免疫治疗成功治疗 1 例肾移植患者的转运中转移性黑色素瘤。

  • 影响因子:3.95
  • DOI:10.1097/CJI.0000000000000319
  • 作者列表:"Sunshine JC","Sosman J","Shetty A","Choi JN
  • 发表时间:2020-03-31
Abstract

:In the era of immunotherapy for cancer, solid organ transplant patients who go on to develop metastatic or locally advanced melanoma offer particularly difficult challenges. New approaches are needed for these patients. We present a case of in-transit metastatic melanoma in a renal transplant patient. The patient was initially managed with talimogene laherparepvec (T-VEC) injections alone with continued local progression. Addition of topical imiquimod 5% cream to intralesional T-VEC resulted in a rapid and dramatic response, with complete clearance of the cutaneous in-transit metastases and without any sign of organ rejection. In solid organ transplant patients who lack surgical options and are not eligible for treatment with a BRAF inhibitor, and for whom treatment with checkpoint inhibitors present risk of organ rejection, T-VEC either alone or in combination with topical imiquimod should be considered for patients with locally advanced disease. This combination should be a consideration, with close observation, in patients with a history of organ transplantation and immunosuppression.

摘要

: 在癌症免疫治疗的时代,实体器官移植患者继续发展为转移性或局部晚期黑色素瘤提供了特别困难的挑战。这些患者需要新的治疗方法。我们介绍了 1 例肾移植患者的转运中转移性黑色素瘤。患者最初采用 talimogene laherparepec (T-VEC) 单独注射治疗,持续局部进展。在病灶内的 T-VEC 中加入外用咪喹莫特 5% 乳膏可产生快速而显著的反应,完全清除皮肤转运中转移灶,无任何器官排斥迹象。在缺乏手术选择且不符合 BRAF 抑制剂治疗条件的实体器官移植患者中,对他们来说,使用检查点抑制剂治疗存在器官排斥的风险,局部晚期疾病患者应考虑 T-VEC 单独或联合局部咪喹莫特。在具有器官移植和免疫抑制病史的患者中,应密切观察这种组合。

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影响因子:6.50
发表时间:2020-03-31
来源期刊:Cancer letters
DOI:10.1016/j.canlet.2019.12.039
作者列表:["Zhou Z","Zhou Q","Wu X","Xu S","Hu X","Tao X","Li B","Peng J","Li D","Shen L","Cao Y","Yang L"]

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