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Disturbance of taste reactivity and other behavioral alterations after bilateral interleukin-1β microinjection into the cingulate cortex of the rat.
双侧白细胞介素 1 β 微量注射到大鼠扣带回皮质后味觉反应性障碍和其他行为改变。
- 影响因子:3.16
- DOI:10.1016/j.bbr.2020.112537
- 作者列表:"László BR","Hormay E","Szabó I","Mintál K","Nagy B","László K","Péczely L","Ollmann T","Lénárd L","Karádi Z
- 发表时间:2020-04-06
Abstract
:The anterior cingulate cortex (ACC), is known to be intimately involved in food-related motivational processes and their behavioral organization, primarily by evaluating hedonic properties of the relevant stimuli. In the present study, the involvement of cingulate cortical interleukin-1β (IL-1β) mediated mechanisms in a) gustation associated facial and somato-motor behavioral patterns of Wistar rats were examined in taste reactivity test (TR). In addition, b) conditioned taste aversion (CTA) paradigm was performed to investigate the role of these cytokine mechanisms in taste sensation associated learning processes, c) the general locomotor activity of the animals was observed in open field test (OPF), and d) the potentially negative reinforcing effect of IL-1β was examined in conditioned place preference test (CPP). During the TR test, species specific behavioral patterns in response to the five basic tastes were analyzed. Response rates of ingestive and aversive patterns of the cytokine treated and the control groups differed significantly in case of the weaker bitter (QHCl, 0.03 mM), and the stronger umami (MSG, 0.5 M) tastes. IL-1β itself did not elicit CTA, it did not interfere with the acquisition of LiCl induced CTA, and it also failed to cause place preference or aversion in the CPP test. In the OPF paradigm, however, significant differences were found between the cytokine treated and the control groups in the rearing and grooming, the number of crossings, and in the distance moved. Our results indicate the involvement of cingulate cortical IL-1β mechanisms in the control of taste perception and other relevant behavioral processes.
摘要
: 前扣带皮层 (ACC),已知密切参与食物相关的动机过程及其行为组织,主要通过评估相关刺激的享乐特性。在本研究中,扣带回皮质白细胞介素-1 β (il-1 β) 介导的机制参与 a) 在味觉反应性试验 (TR) 中检测 Wistar 大鼠的味觉相关面部和躯体运动行为模式。此外,b) 条件性味觉厌恶 (CTA) 范式被用于研究这些细胞因子机制在味觉相关学习过程中的作用,c) 在旷场试验 (OPF) 中观察到动物的一般运动活动,d)在条件位置偏好试验 (CPP) 中检测了 il-1 β 的潜在负增强作用。在 TR 测试期间,分析了响应五种基本味觉的物种特异性行为模式。在较弱的苦味 (QHCl,0.03 mM) 和较强的鲜味 (MSG,0.5 M) 的情况下,细胞因子处理组和对照组的摄入和厌恶模式的反应率显著差异味道。Il-1 β 本身没有引起 CTA,它没有干扰 LiCl 诱导的 CTA 的获得,也没有在 CPP 试验中引起位置偏好或厌恶。然而,在 OPF 范式中,细胞因子处理组和对照组在饲养和梳理、交叉次数和移动距离方面存在显著差异。我们的结果表明扣带回皮质 il-1 β 机制参与味觉和其他相关行为过程的控制。
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